Hydroxyurea and hydroxamic acid derivatives as antitumor drugs

  • Nina SabanEmail author
  • Maro Bujak
Mini Review


Hydroxyurea has been used for decades and it is still valuable for the treatment of some types of cancer. It inhibits ribonucleotide reductase (RNR) enzyme known to be crucial in the conversion of ribonucleotides into deoxyribonucleotides. However, nowadays the main focus has shifted to structurally similar hydroxamic acid derivatives that target specific enzymes involved in cancer progression such as histone deacetylases, matrix metalloproteinases and also RNR.


Hydroxyurea Hydroxamic acid derivatives Cancer 



This paper was financially supported by the Croatian Ministry of Science, Education and Sport’s grants entitled “Molecular characteristic of myofibroblasts derived from Dupuytren’s contracture” (098-0982464-2393). We greatly appreciate the financial help of the Foundation of Croatian Academy of Sciences and Arts.

Conflict of interest statement



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© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Laboratory for Systems Biomedicine, Division of Molecular MedicineRudjer Boskovic InstituteZagrebCroatia

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