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Cancer Chemotherapy and Pharmacology

, Volume 63, Issue 3, pp 567–567 | Cite as

MDA-MB-435 cells are from melanoma, not from breast cancer

  • Marc Lacroix
Letter to the Editor

Abstract

For years, MDA-MB-435 cells have been widely but erroneously used as breast cancer cells with aggressive behaviour. Recent data show that they are in fact melanoma cells. However, many scientists are still unaware of this “new” identity.

Keywords

MDA-MB-435 cells Breast cancer Melanoma Misidentification 

References

  1. 1.
    Ma Z, Molavi O, Haddadi A, Lai R, Gossage RA, Lavasanifar A (2008) Resveratrol analog trans 3,4,5,4′-tetramethoxystilbene (DMU-212) mediates anti-tumor effects via mechanism different from that of resveratrol. Cancer Chemother Pharmacol Feb 20 [Epub ahead of print]. doi: 10.1007/s00280-008-0704-z
  2. 2.
    Lee FY, Smykla R, Johnston K, Menard K, McGlinchey K, Peterson RW, Wiebesiek A, Vite G, Fairchild CR, Kramer R (2008) Preclinical efficacy spectrum and pharmacokinetics of ixabepilone. Cancer Chemother Pharmacol Mar 19 [Epub ahead of print]. doi: 10.1007/s00280-008-0727-5
  3. 3.
    Lacroix M (2008) Persistent use of “false” cell lines. Int J Cancer 122:1–4PubMedCrossRefGoogle Scholar
  4. 4.
    Ross DT, Scherf U, Eisen MB, Perou CM, Rees C, Spellman P, Iyer V, Jeffrey SS, Van de Rijn M, Waltham M, Pergamenschikov A, Lee JC, Lashkari D, Shalon D, Myers TG, Weinstein JN, Botstein D, Brown PO (2000) Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet 24:227–235PubMedCrossRefGoogle Scholar
  5. 5.
    Ellison G, Klinowska T, Westwood RF, Docter E, French T, Fox JC (2002) Further evidence to support the melanocytic origin of MDA-MB-435. Mol Pathol 55:294–299PubMedCrossRefGoogle Scholar
  6. 6.
    Sellappan S, Grijalva R, Zhou X, Yang W, Eli MB, Mills GB, Yu D (2004) Lineage infidelity of MDA-MB-435 cells: expression of melanocyte proteins in a breast cancer cell line. Cancer Res 64:3479–3485PubMedCrossRefGoogle Scholar
  7. 7.
    Rae JM, Creighton CJ, Meck JM, Haddad BR, Johnson MD (2007) MDA-MB-435 cells are derived from M14 melanoma cells–a loss for breast cancer, but a boon for melanoma research. Breast Cancer Res Treat 104:13–19PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.InTextoResearchBaelen (Wallonia)Belgium

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