Cancer Chemotherapy and Pharmacology

, Volume 61, Issue 6, pp 903–909 | Cite as

Prevention of cisplatin nephrotoxicity: state of the art and recommendations from the European Society of Clinical Pharmacy Special Interest Group on Cancer Care

  • Vincent Launay-Vacher
  • Jean-Baptiste Rey
  • Corinne Isnard-Bagnis
  • Gilbert Deray
  • Mikael Daouphars


Antineoplastic drugs used in the treatment of cancers present with variable renal tolerance profiles. Among drugs with a potential for renal toxicity, platinum salts, and especially cisplatin is a well-known agent that may induce acute and chronic renal failure. The mechanisms of its renal toxicity and the means of its prevention are presented in this article which represent the Clinical Recommendation from the Special Interest Group on Cancer Care of the European Society of Clinical Pharmacy (ESCP).


Platinum salts Cisplatin Renal toxicity 


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Vincent Launay-Vacher
    • 1
  • Jean-Baptiste Rey
    • 2
  • Corinne Isnard-Bagnis
    • 3
  • Gilbert Deray
    • 3
  • Mikael Daouphars
    • 4
  1. 1.ICAR, Department of NephrologyHôpital Pitié-SalpêtrièreParisFrance
  2. 2.Department of PharmacyRobert Debré HospitalReimsFrance
  3. 3.Department of NephrologyHôpital Pitié-SalpêtrièreParisFrance
  4. 4.Department of PharmacyHenri Becquerel Cancer CenterRouenFrance

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