Cancer Chemotherapy and Pharmacology

, Volume 61, Issue 5, pp 809–817 | Cite as

Mebendazole inhibits growth of human adrenocortical carcinoma cell lines implanted in nude mice

  • Daniele MartarelliEmail author
  • Pierluigi Pompei
  • Caterina Baldi
  • Giovanni Mazzoni
Original Article


Adrenocortical carcinoma is a rare tumor of the adrenal gland which requires new therapeutic approaches as its early diagnosis is difficult and prognosis poor despite therapies used. Recently, mebendazole has been proved to be effective against different cancers. The aim of our study was to evaluate whether mebendazole may result therapeutically useful in the treatment of human adrenocortical carcinoma. We analyzed the effect of mebendazole on human adrenocortical carcinoma cells in vitro and after implantation in nude mice. In order to clarify mechanisms of mebendazole action, metastases formation, apoptosis and angiogenesis were also investigated. Mebendazole significantly inhibited cancer cells growth, both in vitro and in vivo, the effects being due to the induction of apoptosis. Moreover, mebendazole inhibited invasion and migration of cancer cells in vitro, and metastases formation in vivo. Overall, these data suggest that treatment with mebendazole, also in combination with standard therapies, could provide a new protocol for the inhibition of adrenocortical carcinoma growth.


Adrenocortical carcinoma Mebendazole Nude mice Chemotherapy 



This work was supported by a grant from Rete 7 S.p.A, via Stalingrado, 97/2, 40100 Bologna, Italy.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Daniele Martarelli
    • 1
    Email author
  • Pierluigi Pompei
    • 1
  • Caterina Baldi
    • 1
  • Giovanni Mazzoni
    • 1
  1. 1.Department of Experimental Medicine and Public HealthUniversity of CamerinoCamerino (Macerata)Italy

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