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Cancer Chemotherapy and Pharmacology

, Volume 60, Issue 3, pp 351–356 | Cite as

Biweekly oxaliplatin plus 1-day infusional fluorouracil/leucovorin followed by metronomic chemotherapy with tegafur/uracil in pretreated metastatic colorectal cancer

  • Peng-Chan Lin
  • Wei-Shone Chen
  • Ta-Chung Chao
  • Shung-Haur Yang
  • Chui-Mei Tiu
  • Jin-Hwang Liu
Original Article

Abstract

Purpose

Metronomic chemotherapy, at a minimally toxic dose and with a frequent schedule, is a potentially novel approach to the control of advanced cancer disease via a different mechanism from maximum tolerable doses chemotherapy. Taking advantage of the potential effectiveness of metronomic therapy, tegafur/uracil (UFT) was incorporated into an oxaliplation/infusioanl fluouracil (5-FU)/leucovorin (LV) protocol in this study. The primary endpoints were response rate, time to progression (TTP) and safety profile in 5-FU-pretreated metastatic colorectal cancers (CRCs).

Patients and methods

Twenty-eight patients with metastatic CRCs resistant or refractory to 5-FU/LV were enrolled. Chemotherapy was administrated every 2 weeks sequentially with 2-h infusion of oxaliplatin (85 mg/m2) and LV (200 mg/m2), intravenous bolus 5-FU (400 mg/m2), 22-h infusion of 5-FU (600 mg/m2) on day 1 and then followed by 10-day daily oral UFT (200 mg/m2)/LV (30 mg/m2).

Results

Partial response was seen in ten (35.7%) patients. The median TTP was 5.2 (95% CI: 4.16–6.31) months and the median overall survival was 13.4 (95% CI: 6.39–20.5) months. No grade 3 toxicities above 5% according to National Cancer Institute-Common Toxicity Criteria (NCI-CTC) occurred except sensory neuropathy (10.7%). No grade 4 toxicity, treatment-related mortality or hand–foot syndrome was found.

Conclusions

This study protocol with favorable toxicity profile is thus promisingly effective against 5-FU-pretreated metastatic CRCs. Given the present experience, an evaluation of the regimen as front-line treatment of metastatic CRC is planned.

Keywords

Colorectal cancer Tegafur UFT Oxaliplatin Metronomic chemotherapy 

Notes

Acknowledgments

This study was supported by grant VGH-92–254 from Taipei Veterans General Hospital and grant 94003 from Szu-Yuan Research Foundation, Taipei.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Peng-Chan Lin
    • 1
    • 2
  • Wei-Shone Chen
    • 3
    • 4
  • Ta-Chung Chao
    • 1
  • Shung-Haur Yang
    • 4
  • Chui-Mei Tiu
    • 5
  • Jin-Hwang Liu
    • 1
  1. 1.Division of Medical OncologyTaipei Veterans General Hospital and National Yang-Ming UniversityTaipeiTaiwan, ROC
  2. 2.Division of Hematology and Oncology, Department of Medicine, College of MedicineNational Cheng Kung University HospitalTainanTaiwan, ROC
  3. 3.Division of Experimental SurgeryTaipei Veterans General Hospital, School of Medicine National Yang-Ming UniversityTaipeiTaiwan, ROC
  4. 4.Division of Colorectal SurgeryTaipei Veterans General Hospital, School of Medicine National Yang-Ming UniversityTaipeiTaiwan, ROC
  5. 5.Department of RadiologyTaipei Veterans General Hospital, School of Medicine National Yang-Ming UniversityTaipeiTaiwan, ROC

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