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5-Fluorouracil can cross brain–blood barrier and cause encephalopathy: should we expect the same from capecitabine? A case report on capecitabine-induced central neurotoxicity progressing to coma

  • V. Formica
  • A. Leary
  • D. Cunningham
  • Y. J. Chua
Short Communication

Abstract

Purpose: Capecitabine is a relatively new oral fluoropyrimidine currently licensed for the treatment of colorectal and breast cancer. Results: It has the advantage of oral administration with good tolerability and comparable activity to intravenous 5-fluorouracil. Central neurotoxicity has been described in 5-fluorouracil-treated patients but there is little data regarding capecitabine. We report here a case of reversible capecitabine-induced encephalopathy progressing to coma. Discussion: Literature on fluoropyrimidine-related neurotoxicity will also be reviewed and possible mechanisms of the drug or its metabolites crossing the blood–brain barrier will be discussed.

Keywords

5-Fluorouracil Encephalopathy Capecitabine 

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • V. Formica
    • 1
  • A. Leary
    • 1
  • D. Cunningham
    • 1
  • Y. J. Chua
    • 1
  1. 1.Department of MedicineRoyal Marsden HospitalSuttonUK

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