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Psychotherapeut

, Volume 56, Issue 3, pp 203–210 | Cite as

Bedeutung von Stress bei chronischer Erschöpfung

Ein psychobiologischer Ansatz
  • Urs M. NaterEmail author
Übersichten

Zusammenfassung

In diesem Beitrag soll ein neuer Erklärungsansatz für das Entstehen von chronischer Erschöpfung vorgestellt werden. Dieser geht von der Beobachtung aus, dass die endokrine Stressachse bei traumatischen Erfahrungen zu einem frühen Zeitpunkt im Leben eines Menschen nachhaltig in ihrer Funktionstüchtigkeit eingeschränkt werden kann. Es finden sich bei Patienten mit dem chronischen Erschöpfungssyndrom („chronic fatigue syndrome“, CFS) signifikant mehr Berichte über traumatische Erfahrungen in der Kindheit, wie z. B. sexuellen Kindesmissbrauch, als bei gesunden Kontrollen. In einem so kritischen und vulnerablen Stadium der Entwicklung des biologischen Stresssystems kann die Sensitivität des Systems im Erwachsenenalter dergestalt eingeschränkt sein, dass eine adäquate Reaktion auf neuartige Stressoren nicht mehr oder nur noch mit Mühe möglich ist. Es ist leicht vorstellbar, dass als Konsequenz dieser Entwicklungen eine nachhaltige Dysregulierung auf endokriner und immunologischer Ebene stattfinden und die Ausbildung von chronischer Erschöpfung begünstigt werden kann.

Schlüsselwörter

Mentale Prozesse Lebensverändernde Ereignisse Hypothalamus-Hypophysen-Nebennierendrinden-Achse Immunsystem Endokrines System 

Role of stress in chronic fatigue

A psychobiological approach

Abstract

In this review article a novel approach to the explanation of chronic fatigue is presented. It has long been known that patients suffering from chronic fatigue syndrome (CFS) have reported increased occurrencesof traumatic experiences early in life compared to healthy individuals. Such experiences have been found to substantially impact on biological regulation processes later in life and thus alter sensitivity to stressful stimuli in adulthood. In CFS research has shown that patients display altered endocrine and immune stress regulation. A summary of current research in this area is given and the role of both childhood and adulthood stressors in biological regulation processes in CFS is discussed.

Keywords

Mental processes Life events Hypothalamic adrenal pituitary axis Immune system Endocrine system 

Notes

Danksagung

Der Autor bedankt sich für die Unterstützung durch den Schweizerischen Nationalfonds sowie durch die Volkswagen-Stiftung.

Interessenkonflikt

Keine Angabe.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Klinische BiopsychologiePhilipps-Universität MarburgMarburgDeutschland

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