Annals of Hematology

, Volume 79, Issue 5, pp 239–242 | Cite as

Prevalence of prothrombin 20210A allele and methylenetetrahydrofolate reductase C677T genetic mutations in the Chinese population

  • C. H. Ho
ORIGINAL ARTICLE

Abstract

 From July 1997 to June 1998, a total of 1323 subjects, including 1180 controls, 94 patients with diabetes mellitus, and 49 patients with deep-vein thrombosis, varying in age and gender, were consecutively entered into our study. Their mean (±SD) age was 50.0±18.0 years, range 1–99 years; 930 were male and 393 were female. None of the subjects was found to have abnormal prothrombin 20210A allele mutation. In total, 150 subjects (11.3%) were found to have a homozygous 677 C→T mutation of the methylenetetrahydrofolate reductase gene, in which 125 were controls (10.6%), 17 were diabetics (18.1%) and 8 were patients with deep-vein thrombosis (16.3%). However, 524 subjects (39.6%) were found to have a heterozygous methylenetetrahydrofolate reductase 677 C→T mutation. We suggested that the Chinese race does not have the prothrombin 20210A allele, but can carry the 677 C→T mutation of the methylenetetrahydrofolate reductase gene.

Key words Deep-vein thrombosis Methylenetetrahydrofolate reductase Prevalence Prothrombin 20210A allele 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • C. H. Ho
    • 1
  1. 1.Division of Hematology, Veterans General Hospital, Taipei, Taiwan 11217, Republic of China e-mail address: chho@vghtpe.gov.tw Tel.: +886-2-28757106 Fax: +886-2-28757106TW

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