Annals of Hematology

, Volume 79, Issue 4, pp 222–225 | Cite as

T-cell lineage acute lymphoblastic leukemia with chromosome 5 abnormality in a patient with Crohn's disease and lipoid nephrosis

  • L. Pérard
  • X. Thomas
  • H. Jaumain
  • G. Theuil
  • M. Bret
  • B. Coronel
  • C. Charrin
  • P. Boulétreau
CASE REPORT

Abstract

 We describe a 17-year-old patient with a documented history of Crohn's disease (CD) and of minimal-change nephrotic syndrome (MCNS) in whom a diagnosis of T-cell acute lymphoblastic leukemia (ALL) was made. The diagnosis of ALL was established by morphological examination of bone-marrow aspirates and confirmed by means of immunophenotypic analysis showing the involvement of T-cell lineage leukemic cells. The lymphoid clone showed a karyotypic abnormality involving the long arm of chromosome 5 in a translocation (5;6). Few cases of CD complicated by ALL have been previously reported. The present one is the first case combining CD and ALL in a patient with a past history of MCNS. This raises the possibility of a relationship among those diseases. The possible mechanisms for such a relationship are discussed here.

Key words Acute lymphoblastic leukemia Crohn's disease Lipoid nephrosis Chromosome 5 abnormality 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • L. Pérard
    • 1
  • X. Thomas
    • 2
  • H. Jaumain
    • 1
  • G. Theuil
    • 3
  • M. Bret
    • 1
  • B. Coronel
    • 1
  • C. Charrin
    • 3
  • P. Boulétreau
    • 1
  1. 1.Service d'Anesthesie et de Réanimation, Hôpital Edouard Herriot, Lyon, FranceFR
  2. 2.Service d'Hématologie, Hôpital Edouard Herriot, 5, place d'Arsonval, 69437 Lyon cedex 03France e-mail: xavier.thomas@chu-lyon.fr Tel.: +33-4-72117395 Fax: +33-4-72117404FR
  3. 3.Laboratoire d'Hématologie et de Cytogénétique, Hôpital Edouard Herriot, Lyon, FranceFR

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