Annals of Hematology

, Volume 75, Issue 5–6, pp 243–246 | Cite as

Treatment with rhG-CSF for osteomyelitis in a patient with p47-phox-deficient chronic granulomatous disease

  • H. Isotani
  • Y. Fukumoto
  • H. Kawamura
  • M. Sasada
  • K. Hattori
  • T. Fujiwara
  • Y. Kobayashi
CASE REPORT

Abstract

 A 24-year-old woman with osteomyelitis was diagnosed as having p47-phox-deficient chronic granulomatous disease (CGD). The patient showed a marked deficiency of p47-phox, which is very rare in Japan. As the clinical response to various antibiotics including sulfamethoxazole-trimethoprim was not satisfactory, we added recombinant human granulocyte colony-stimulating factor (rhG-CSF) to the treatment protocol. We report the beneficial clinical course of the patient, together with the effect of rhG-CSF on the granulocyte function, and the present report indicates that rhG-CSF is useful for the treatment of antibiotic-resistant infection in the variant type of p47-phox-defective CGD.

Key words Chronic granulomatous disease p47-phox deficiency G-CSF Superoxide anion (O2 Osteomyelitis 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • H. Isotani
    • 1
  • Y. Fukumoto
    • 1
  • H. Kawamura
    • 1
  • M. Sasada
    • 2
  • K. Hattori
    • 3
  • T. Fujiwara
    • 3
  • Y. Kobayashi
    • 3
  1. 1.Department of Internal Medicine, Hirakata City Hospital, 2-14-1 Kinyahonmachi, Hirakata City, Osaka 573, JapanJP
  2. 2.College of Medical Technology, Kyoto University, 53 Shogoin-Kawaharacho, Kyoto City, Kyoto 606, JapanJP
  3. 3.Department of Pediatrics, Kansai Medical University, 10–15 Fumizonocho, Moriguchi City, Osaka 570, JapanJP

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