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Annals of Hematology

, Volume 75, Issue 1–2, pp 67–68 | Cite as

Red cell aplasia caused by parvovirus B19 in AIDS: use of i.v. immunoglobulin

  • P. R. Koduri
  • R. Kumapley
  • N. D. Khokha
  • A. R. Patel
CASE REPORT

Abstract

 We describe the case of a 34-year-old man with AIDS who developed severe anemia due to chronic pure red cell aplasia (PRCA) caused by parvovirus B19. Following initial treatment with an infusion of intravenous immunoglobulin (IVIg), 1 g/kg, PRCA resolved, but there was a recurrence of severe anemia in 3 months. Retreatment with 2 g/kg IVIg over 2 days resulted in normalization of hemoglobin and a significantly longer remission duration. Two doses of 0.4 g/kg IVIg q 4 wk failed to prevent a relapse of PRCA in our patient. The dose and schedule of IVIg in the treatment of PRCA caused by parvovirus B19 in AIDS requires further definition.

Key words Parvovirus B19 AIDS Red cell aplasia Immunoglobulin 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • P. R. Koduri
    • 1
  • R. Kumapley
    • 1
  • N. D. Khokha
    • 1
  • A. R. Patel
    • 1
  1. 1.Department of Medicine, Division of Hematology, Cook County Hospital, Hektoen Building, Room 817, 627 S. Wood, Chicago, IL 60612, USACK

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