Annals of Hematology

, Volume 75, Issue 1–2, pp 65–66

Late hemorrhagic disease of the newborn as a cause of intracerebral bleeding

  • P. Solves
  • A. Altés
  • G. Ginovart
  • J. Demestre
  • Jordi Fontcuberta
CASE REPORT

Abstract

 We report a case of a 4-week-old female who presented with late hemorrhagic disease of the newborn (HDN). The newborn was previously healthy, and she received 1 mg of intramuscular vitamin K at birth. She was exclusively breast-fed. At 4 weeks she began bleeding at the umbilicus and 4 days after she suffered an intracranial hemorrhage. Coagulation studies showed a deficiency of vitamin K-dependent coagulation factors, and the normalization of all clotting studies after administration of vitamin K confirmed the diagnosis of HDN. Our conclusions are that physicians must be alert to mild bleeding in newborns and that prophylaxis with 1 mg of intramuscular vitamin K at birth may be insufficient to prevent late HDN.

Key words Late HDN Vitamin K Intracranial hemorrhage 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • P. Solves
    • 1
  • A. Altés
    • 1
  • G. Ginovart
    • 2
  • J. Demestre
    • 2
  • Jordi Fontcuberta
    • 1
  1. 1.Thrombosis and Hemostasis Unit, Department of Hematology, Hospital de Sant Pau, Avenida S.A.M. Claret, 167., E-08025 Barcelona, SpainES
  2. 2.Department of Pediatrics, Hospital de Sant Pau, Barcelona, SpainES

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