Annals of Hematology

, Volume 73, Issue 1, pp 47–50 | Cite as

A case of localized Castleman's disease with systemic involvement: treatment and pathogenetic aspects

  • G. J. Veldhuis
  • A. H. D. van der Leest
  • J. T. M. de Wolf
  • E. G. E. de Vries
  • E. Vellenga
CASE REPORT

Abstract

 A patient is presented who had Castleman's disease with constitutional symptoms, a palpable supraclavicular/axillar mass, and a microcytic anemia, among other laboratory abnormalities, including elevated levels of interleukin-6. Treatment consisted of irradiation of the involved area, with subsequent disappearance of all symptoms and normalization of the laboratory abnormalities. Iron kinetic studies demonstrated a hypoproliferative erythropoiesis, which normalized after radiotherapy. Hypoproliferative erythopoiesis could not be ascribed to serum inhibitors, since normal burst-forming units were observed in the absence or presence of autologous serum. The role of interleukin-6 in relation to Castleman's disease is highlighted.

Key words Giant lymph-node Hyperplasia Castleman's disease Radiotherapy Interleukin-6 Anemia 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • G. J. Veldhuis
    • 1
  • A. H. D. van der Leest
    • 2
  • J. T. M. de Wolf
    • 3
  • E. G. E. de Vries
    • 1
  • E. Vellenga
    • 3
  1. 1.Department of Internal Medicine, Division of Medical Onocology, University Hospital Groningen, P.O.Box 30.001, NL-9700 RB Groningen, The NetherlandsNL
  2. 2.Department of Radiotherapy, University Hospital Groningen, P.O. Box 30.001, NL-9700 R.B. Groningen, The NetherlandsNL
  3. 3.Department of Internal Medicine, Division of Hematology, University Hospital Groningen, P.O. Box 30.001, NL-9700 R.B. Groningen, The NetherlandsNL

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