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Annals of Hematology

, Volume 79, Issue 2, pp 95–98 | Cite as

Complete haematological and cytogenetic response to interferon alpha-2a of a myeloproliferative disorder with eosinophilia associated with a unique t(4;7) aberration

  • P. Schöffski
  • A. Ganser
  • U. Pascheberg
  • G. Büsche
  • B. Gaede
  • B. Hertenstein
CASE REPORT

Abstract

 A female patient with eosinophilia and cardiac symptoms was found to have a unique chromosomal aberration [t(4;7)(q11;p13)] of bone-marrow precursors. The disorder was classified as a chronic myeloproliferative syndrome with eosinophilia. Due to a significant increase in the white blood cell and eosinophil count during initial treatment with prednisone and hydroxyurea, Interferon alpha-2a was administered at a dose of 3–5×106 I.U. s.c., five times per week, and induced a long-term complete haematological and cytogenetic response. The clinical features of this case are presented and discussed in the context of the current literature.

Key words Chronic myeloproliferative syndrome Eosinophilia Hypereosinophilic syndrome Translocation t(4;7)(q11;p13) Interferon alpha-2a Cytogenetic response 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • P. Schöffski
    • 1
  • A. Ganser
    • 1
  • U. Pascheberg
    • 2
  • G. Büsche
    • 3
  • B. Gaede
    • 4
  • B. Hertenstein
    • 1
  1. 1.Department of Haematology/Oncology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany e-mail: Schoeffski.Patrick@MH-Hannover.de Tel.: +49-511-5324077 Fax: +49-511-5324077DE
  2. 2.Gemeinschaftspraxis für Laboratoriumsmedizin Dr. Eberhardt et al., Brauhausstrasse 4, 44137 Dortmund, GermanyDE
  3. 3.Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, GermanyDE
  4. 4.Schwerpunktpraxis Hämatologie/Onkologie, Calenberger Esplanade 1, 30169 Hannover, GermanyDE

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