Quick complete response achievement with venetoclax and azacitidine in a case of relapsed disseminated blastic plasmacytoid dendritic cell neoplasm

  • Matteo PicciniEmail author
  • Giuseppe Gaetano Loscocco
  • Giacomo Gianfaldoni
  • Pietro Grieco
  • Giuseppina Palmieri
  • Sofia Pilerci
  • Barbara Scappini
  • Alberto Bosi
Letter to the Editor

Dear Editor,

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and extremely aggressive myeloid malignancy arising from dendritic cell (DC) precursors typically affecting skin and/or bone marrow. Despite excellent complete response (CR) rates with induction chemotherapy, the disease has a marked tendency to relapse and become chemoresistant, with an overall dismal outcome. Frontline treatment with acute myeloid leukemia-like and acute lymphoblastic leukemia-like regimens resulted in disease-free and overall survival advantage, although allogeneic stem cell transplantation appears to be the only therapeutic approach with potential for disease eradication and long-term survivorship [1]. Data on efficacy of specific therapeutic regimens in the relapsed/refractory (R/R) setting are lacking, mainly because of the rarity of this disease entity. Conventional chemotherapy seems to provide only limited and transient clinical benefit [2]. Recently, CD123-directed cytotoxin...


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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.Informed consent.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Azienda Ospedaliera Universitaria CareggiFirenzeItaly

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