Magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography/computed tomography findings in neurolymphomatosis: an uncommon presentation of diffuse large B cell lymphoma

  • Marta D. SwitlykEmail author
  • Annette T. Skeie
  • Marius Lund-Iversen
  • Bjørn Østenstad
Letter to the Editor

Dear Editor,

Neurolymphomatosis (NL) is an uncommon condition characterized by direct invasion of the peripheral nervous system by lymphoma, mostly B cell non-Hodgkin lymphoma [1, 2]. NL refers to direct infiltration of the endoneurium by lymphoma cells, a process that should be distinguished from compression or secondary invasion of the nerves by adjacent lymphadenopathy, extranodal or meningeal lymphomatous masses, and subarachnoid seeding of lymphoma [3, 4]. The most common clinical presentation of NL is painful peripheral neuropathy or radiculopathy; however, limited information is available on the mode of presentation, clinical course, results of diagnostic procedures, and response to therapy because of the rarity of this condition [5].

A 73-year-old male patient developed progressive left lower extremity weakness and severe pain in the left gluteal region radiating to the lower extremity. The patient had no prior history of lymphoma. He had previously been operated on multiple...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Radiology, RadiumhospitaletOslo University HospitalOsloNorway
  2. 2.Department of Pathology, RadiumhospitaletOslo University HospitalOsloNorway
  3. 3.Department of Oncology, RadiumhospitaletOslo University HospitalOsloNorway

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