Annals of Hematology

, Volume 98, Issue 11, pp 2609–2611 | Cite as

Efficacy and safety of bosutinib in chronic phase CML patients developing pleural effusion under dasatinib therapy

  • Mario TiribelliEmail author
  • Elisabetta Abruzzese
  • Isabella Capodanno
  • Federica Sorà
  • Elena Trabacchi
  • Alessandra Iurlo
  • Luigiana Luciano
  • Gianni Binotto
  • Massimiliano Bonifacio
  • Mario Annunziata
  • Monica Crugnola
  • Renato Fanin
Letter to the Editor

Dear Editor,

Dasatinib is a second-generation (2G) tyrosine-kinase inhibitor (TKI) approved for the first- and second-line treatment of chronic myeloid leukemia (CML) patients. Though highly effective, dasatinib displays a distinct safety profile, with pleural effusion (PE) occurring in a significant proportion of patients [1, 2]. Among factors associated with dasatinib-related PE, concomitant pulmonary and cardiovascular diseases have emerged as the most common [3]. Bosutinib is another 2G-TKI that has proved to be effective in CML patients failing previous TKIs, with relatively limited toxicity, represented mainly by gastrointestinal and cutaneous side effects [4]. Generally considered safe from the cardiovascular point of view, bosutinib has been seldom associated with PE [5]. To date, little is known about cross-intolerance between dasatinib and bosutinib, and scarce data have been reported on the incidence of PE with bosutinib in patients with pleuropulmonary toxicity under...


Author contribution

M. Tiribelli designed the study, analyzed the data, and wrote the draft of the manuscript. All authors provided clinical data, helped in the analysis and interpretation of the results, critically revised the manuscript, and approved the final draft for submission.

Compliance with ethical standards

Conflict of interest

M. Tiribelli and G. Binotto received honoraria from Novartis, BMS, Pfizer, and Incyte. A. Iurlo received honoraria from Novartis, Pfizer, and Incyte. M. Bonifacio received honoraria from Amgen, Incyte, Pfizer, and Novartis. M. Crugnola received honoraria from Novartis, Incyte, and Jassen.

All other authors have no conflict of interest to report.

Ethical approval

This was a non-interventional retrospective evaluation of patient’s chart data, so no ethical approval for its conduct was necessary; for the same reason, no informed consent had to be obtained from the included patients.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Mario Tiribelli
    • 1
    Email author
  • Elisabetta Abruzzese
    • 2
  • Isabella Capodanno
    • 3
  • Federica Sorà
    • 4
  • Elena Trabacchi
    • 5
  • Alessandra Iurlo
    • 6
  • Luigiana Luciano
    • 7
  • Gianni Binotto
    • 8
  • Massimiliano Bonifacio
    • 9
  • Mario Annunziata
    • 10
  • Monica Crugnola
    • 11
  • Renato Fanin
    • 1
  1. 1.Division of Hematology and BMT, Department of Medical AreaUniversity of UdineUdineItaly
  2. 2.Department of HematologyTor Vergata University HospitalRomeItaly
  3. 3.Hematology UnitAzienda Unità Sanitaria Locale-IRCCSReggio EmiliaItaly
  4. 4.Institute of HematologyUniversità Cattolica Sacro CuoreRomeItaly
  5. 5.Hematology and BMT Unit, Department of Hematology and OncologyG. da Saliceto HospitalPiacenzaItaly
  6. 6.Hematology DivisionFoundation IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoMilanItaly
  7. 7.Hematology Unit, Federico II HospitalUniversity of NaplesNaplesItaly
  8. 8.Hematology and Clinical Immunology, Department of MedicinePadua School of MedicinePaduaItaly
  9. 9.Section of Hematology, Department of MedicineUniversity of VeronaVeronaItaly
  10. 10.Hematology UnitOspedale CardarelliNaplesItaly
  11. 11.Hematology Unit and BMT CenterAzienda Ospedaliero-Universitaria di ParmaParmaItaly

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