Autoimmune hemolytic anemia in refractory hairy cell leukemia on dabrafenib and trametinib

  • Damond Barrick NgEmail author
  • Gary Schiller
  • Edward Ha
Letter to the Editor

Dear Editor,

Hairy cell leukemia (HCL) is a rare, indolent B cell malignancy characterized by bone marrow infiltration, splenomegaly, pancytopenia, and neoplastic cells morphologically with cytoplasmic “hair-like” projections [1]. Analogous to other B cell disorders, autoimmune diseases have been reported in HCL; however, autoimmune hemolytic anemia (AIHA) has seldom been reported [2, 3].

We report a 74-year-old man with refractory HCL on dabrafenib/trametinib who presented with fatigue, dyspnea, dark red urine, and dizziness exacerbated by hot showers. He was diagnosed with HCL at the age of 53 years and treated with cladribine resulting in a complete response (CR) that lasted 15 years before requiring reinduction. Three years later, the patient was enrolled in a moxetumomab pasudotox trial for refractory HCL, but his bone marrow persistently exhibited disease after six cycles. Sustained partial remission was achieved while on dabrafenib/trametinib trial for 1.5 years prior to...


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Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.David Geffen School of MedicineUniversity of California, Los AngelesLos AngelesUSA
  2. 2.Division of Hematology/Oncology, Department of MedicineUniversity of California, Los AngelesLos AngelesUSA
  3. 3.Department of MedicineUniversity of California, Los AngelesLos AngelesUSA

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