BCR-ABL1- and CBFB-MYH11-positive chronic myeloid leukemia presenting with primary blast crisis and marrow fibrosis
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Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the BCR-ABL1 fusion gene . Bone marrow fibrosis leading to dry tap aspiration has been reported in patients with CML, frequently in association with blast crisis . CBFB-MYH11 is a genomic abnormality in acute myeloid leukemia (AML) that predicts a favorable prognosis . Here, we report a case of BCR-ABL1- and CBFB-MYH11-positive CML with primary blast crisis (CML-pBC) and marrow fibrosis.
This work was supported in part by grants from the Ministry of Education, Culture, Sports, Science, and Technology in Japan (17K09928 0001), the Yasuda Medical Foundation, the Foundation for Promotion of Cancer Research in Japan, the Project Mirai Cancer Research Grants, and the Japan Leukemia Research Fund.
Compliance with ethical standards
Written informed consent was obtained from the patients for publication.
Conflict of interest
The authors declare that they have no conflict of interest.
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