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BAM conditioning before autologous transplantation for lymphoma: a study on behalf of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)

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Abstract

High-dose chemotherapy before autologous transplantation is a therapeutic option as consolidation in primary or relapsed lymphoma. Even if BEAM conditioning is generally used, alternative conditioning regimens have been published. The purpose of this study was to assess the outcome of 177 adult patients with lymphoma whose conditioning treatment included a BAM (busulfan, aracytine, and melphalan) regimen. With a median follow-up of 17.4 months, 2-year estimates of overall survival and progression-free survival for the entire group were 87% and 70.5%, respectively. Mucositis was the main reported complications and infectious episodes were described in 80.2% of patients. According to multivariate analysis, high performance status and age at diagnosis were adverse factors for survival and increased the risk of disease relapse and death. Despite its limitations, this retrospective study suggests that BAM combination is a valid conditioning regimen in lymphoma patients, with an acceptable rate of toxicity.

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Authors and Affiliations

  1. Department of Clinical Hematology, Institut de Cancérologie Lucien Neuwirth, Saint-Priest-en-Jarez, France

    Jérôme Cornillon, Elisabeth Daguenet & Caroline Lejeune

  2. Centre Hospitalo-Universitaire Clermont-Ferrand, Clermont-Ferrand, France

    Jacques-Olivier Bay

  3. Centre Hospitalier Régional Universitaire Besançon, Inserm UMR 1098, Besançon, France

    Adrien Chauchet

  4. Centre Hospitalier Lyon Sud, Lyon, France

    Gilles Salles

  5. Centre Henri Becquerel, Rouen, France

    Nathalie Contentin

  6. Centre Léon Bérard, Lyon, France

    Emmanuelle Nicolas-Virelizier

  7. Centre Hospitalo-Universitaire d’Angers, Angers, France

    Mélanie Mercier

  8. Centre Hospitalo-Universitaire Tours, Tours, France

    Nicolas Vallet & Emmanuel Gyan

  9. Centre Hospitalier Régional Orléans, Orléans, France

    Magda Alexis

  10. Centre Hospitalo-Universitaire Dijon, Dijon, France

    Marie-Lorraine Chrétien

  11. Centre Hospitalo-Universitaire Nice, Nice, France

    Thomas Cluzeau

  12. Centre Hospitalo-Universitaire Toulouse, Toulouse, France

    Anne Huynh

  13. Centre Hospitalo-Universitaire Reims, Reims, France

    Chantal Himberlin

  14. Centre Hospitalier Régional Metz, Metz, France

    Véronique Dorvaux

  15. Département d’Onco-Hématologie adulte, Hôpital Saint-Louis AP-HP, Paris, France

    Sandy Amorim

  16. Département d’Hématologie Greffe, Hôpital Saint-Louis AP-HP, Paris, France

    Régis Peffault de Latour

Authors
  1. Jérôme Cornillon
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  2. Elisabeth Daguenet
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  3. Jacques-Olivier Bay
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  4. Adrien Chauchet
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  5. Gilles Salles
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  6. Nathalie Contentin
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  7. Emmanuelle Nicolas-Virelizier
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  8. Mélanie Mercier
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  9. Nicolas Vallet
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  11. Marie-Lorraine Chrétien
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  13. Anne Huynh
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  15. Véronique Dorvaux
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  16. Sandy Amorim
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  17. Caroline Lejeune
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  18. Régis Peffault de Latour
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  19. Emmanuel Gyan
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Corresponding author

Correspondence to Jérôme Cornillon.

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Conflict of interest

EG received research support from Pierre Fabre. The remaining authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the SFGM-TC scientific council and performed according to the SFGM-TC guidelines and in accordance with the principles of the declaration of Helsinki.

Informed consent

Informed consent was obtained from all subjects.

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Supplementary Table 1

Main extra-hematological toxicities according to WHO scale or CTCAE v4.0. (DOC 35 kb)

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Cornillon, J., Daguenet, E., Bay, JO. et al. BAM conditioning before autologous transplantation for lymphoma: a study on behalf of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). Ann Hematol 98, 1973–1980 (2019). https://doi.org/10.1007/s00277-019-03704-z

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  • DOI: https://doi.org/10.1007/s00277-019-03704-z

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