Pregnancy rate and outcome of pregnancies in long-term survivors of Hodgkin’s lymphoma

  • Francesco GaudioEmail author
  • Claudia Nardelli
  • Paola Masciandaro
  • Tommasina Perrone
  • Filomena Emanuela Laddaga
  • Paola Curci
  • Raffaella Depalo
  • Ettore Cicinelli
  • Giorgina Specchia
Original Article


Thanks to the increased number of young survivors of Hodgkin’s lymphoma (HL), management of the pregnancies of women who have a history of exposure to chemotherapies and radiation therapy is becoming increasingly common. Many patients and clinicians are worried that pregnancy after the diagnosis of HL may increase the risk of relapse, despite a lack of empirical evidence to support such concerns. In the present study, we included 89 women diagnosed with HL between 2006 and 2015 under the age of 50 years, who were in complete remission and alive without relapse > 1 year after treatment. We determined the pregnancy rate, time to pregnancy, and the disease-free survival. We found no evidence of significant impairment of the fertility of female HL long-term survivors and no evidence that a pregnancy increases the relapse rate among women in remission from HL. Survivors of HL need to consider a range of factors when deciding on future reproduction.


Fertility Pregnancy Hodgkin 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

This article does not contain any studies with animals performed by any of the authors.

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Francesco Gaudio
    • 1
    Email author
  • Claudia Nardelli
    • 2
  • Paola Masciandaro
    • 2
  • Tommasina Perrone
    • 1
  • Filomena Emanuela Laddaga
    • 3
  • Paola Curci
    • 1
  • Raffaella Depalo
    • 2
  • Ettore Cicinelli
    • 2
  • Giorgina Specchia
    • 1
  1. 1.Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology SectionUniversity of BariBariItaly
  2. 2.Department of Biomedical Science and Human Oncology, Obstetrics and Gynecology UnitUniversity of BariBariItaly
  3. 3.Department of Emergency and Organ Transplantation (D.E.T.O.), Pathology SectionUniversity of BariBariItaly

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