Combination of decitabine, idarubicin, cytarabine, and G-CSF (DIAG) regimen for the treatment of high-risk myelodysplastic syndrome and acute myeloid leukemia
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Sixty to eighty percent of patients with newly diagnosed acute myeloid leukemia (AML) can achieve complete remission (CR) after intensive chemotherapy. However, current therapy remains unsatisfactory for high-risk AML patients, including the elderly, relapsed, refractory, and secondary AML . Myelodysplastic syndrome (MDS) comprises a very different group of myeloid malignancies with very distinct natural histories. Interventions have been evolved significantly over the last decade in high-risk disease. However, the median survival of these patients was only 0.5 years . Generally, the effect of intensive chemotherapy on these patients is insufficient because of drug resistance, poor performance status (PS), dysfunction of multiple organs, and high treatment-related toxicities, leading to high early death (ED) rate. Novel agents and regimens have been developing for this group of patients with AML and high-risk MDS [3, 4, 5, 6].
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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