Successful retreatment with 3-week rituximab-bendamustine with high-dose dexamethasone in patients with relapsed/refractory mantle cell lymphoma

  • Wolfgang Lamm
  • Barbara Kiesewetter
  • Hannah Puhr
  • Werner Dolak
  • Marius E. Mayerhöfer
  • Markus Raderer
Letter to the Editor

Dear Editor,

Mantle cell lymphoma (MCL) is an aggressive subtype of B cell non-Hodgkin’s lymphoma (NHL) which accounts for approximately 6% of all NHLs [1]. Roughly 5% of patients suffer from the more aggressive blastic variant MCL [2].

Bendamustine in combination with rituximab (RB) has shown promising results in different phase III trials in elderly patients unfit for high-dose chemotherapy in different kinds of lymphomas, including MCL with response rates of approximately 86–93% [3, 4, 5, 6].

Bendamustine in relapsed/refractory lymphomas including MCL also showed promising results [7]. RB retreatment, however, has never been investigated before. In view of this, we have performed a retrospective single-center analysis to evaluate the clinical efficacy and safety of RB retreatment in patients with MCL.

Seven patients were retreated with RB (Table 1), which was given on a 3-week basis along with dexamethasone. The median age was 81 years (range 65–83). Additional patients’...


Compliance with ethical standards

All authors gave their informed consent for this study.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Wolfgang Lamm
    • 1
  • Barbara Kiesewetter
    • 1
  • Hannah Puhr
    • 1
  • Werner Dolak
    • 2
  • Marius E. Mayerhöfer
    • 3
  • Markus Raderer
    • 1
  1. 1.Department of Medicine I, Clinical Division of OncologyMedical University of ViennaViennaAustria
  2. 2.Department of Medicine III, Clinical Division of Gastroenterology and HepatologyMedical University of ViennaViennaAustria
  3. 3.Department of Biomedical Imaging and Image-guided TherapyMedical University of ViennaViennaAustria

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