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Atypical bortezomib-induced neutrophilic dermatosis

  • Alain Lescoat
  • Alain Dupuy
  • Nicolas Belhomme
  • Nathalie Stock
  • Martine Sebillot
  • Olivier Decaux
  • Patrick Jégo
  • Catherine Droitcourt
Letter to the Editor
  • 6 Downloads

Dear Editor,

A 76-year-old man was treated with prednisone-melphalan and sub-cutaneous injections of bortezomib for an IgG kappa multiple myeloma (MM). On day 25 of the first chemotherapy cycle, the patient presented with painless red-to-purple edematous, bullous, or ulcerated, and hemorrhagic plaques, involving the forehead, the dorsal face of fingers, and both ankles (Fig.  1a, b). The complete blood count was normal. Skin biopsy revealed an infiltrate of neutrophils located within the dermis with partially destroyed hair follicles, but without vasculitis, dermal edema, or any type of tumor cell (Fig.  1c). Echocardiography, microbiological skin samples, and blood cultures were normal. Considering the histologic features and the patient’s clinical and drug history, we hypothesized bortezomib-induced neutrophilic dermatosis (ND).

Notes

Authors’ contribution

All of the authors participated in the preparation of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Alain Lescoat
    • 1
    • 2
    • 3
  • Alain Dupuy
    • 4
  • Nicolas Belhomme
    • 1
  • Nathalie Stock
    • 5
  • Martine Sebillot
    • 1
  • Olivier Decaux
    • 1
  • Patrick Jégo
    • 1
    • 2
  • Catherine Droitcourt
    • 4
  1. 1.Department of Internal MedicineCHU Rennes, University of Rennes 1RennesFrance
  2. 2.Univeristy of Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) – UMR_S 1085RennesFrance
  3. 3.Department of Internal MedicinePontchaillou University HospitalRennes cedex 9France
  4. 4.Department of DermatologyCHU Rennes, University of Rennes 1, INSERM CIC1414, UPRES EA 7449 REPERES (Pharmacoepidemiology and access to health care), University Rennes 1 and French School of Public HealthRennesFrance
  5. 5.Department of PathologyCHU Rennes, University of Rennes 1RennesFrance

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