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Treating synchronous bilateral ocular adnexal marginal zone lymphoma: the consortium for improving survival of lymphoma study

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Abstract

Both-side synchronous involvement has been reported to account for 7–24% of ocular adnexal marginal zone lymphoma (OAML). We conducted a retrospective analysis to identify the clinical features and treatment outcomes of synchronous bilateral OAML (SB-OAML) by treatment modality. We analyzed patients with a histologic diagnosis of SB-OAML, excluding metachronous bilateral involved OAML. We enrolled a total of 95 patients for this analysis, 36 males and 59 females; the median patient age was 42 years (range 16–77 years). Eleven (11.6%) patients had been treated with chemotherapy or chemo-immunotherapy (eight R-CVP, two CVP, and one R-CHOP). The median number of treatments was 6 (range 6–8); there were 9 complete responses (CRs; 81.8%) and 2 partial responses (PRs; 18.2%). Nearly all patients (88.4%) received radiotherapy in both eyes, and the median radiation dose was 27 Gy (range 20–40 Gy) to each eye; 68 CRs (80.9%) and 14 PRs (16.7%) were achieved. Ten-year progression-free survival (PFS) and overall survival (OS) rates were 79.8 and 91.1%, respectively. Radiotherapy continued to be an independent prognostic marker, with the hazard of progression (P = 0.036). Eleven patients (13.1%) had surgery for cataract treatment during follow-up, and patients who received low-dose radiation (< 30.3 Gy) experienced fewer cataract operations. SB-OAML was predominantly observed in young females, and they had good response and prognosis regardless of treatment modalities. Low-dose radiotherapy to both eyes showed a tendency of longer PFS than did chemotherapy and could decrease cataract operations.

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Authors and Affiliations

  1. Department of Internal Medicine, Dong-A University Hospital, Busan, South Korea

    Sung Yong Oh, Ji Hyun Lee & Seok Jae Huh

  2. Department of Medicine, Samsung Medical Center, Sunkyunkwan University School of Medicine, Seoul, South Korea

    Won Seog Kim & Seok Jin Kim

  3. Division of Hematology/Oncology, Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea

    Hye-Jin Kang

  4. Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Dok Hyun Yoon, Jung Yong Hong & Cheolwon Suh

  5. Department of Hematology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea

    Won Sik Lee

  6. Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea

    Hyo Jung Kim

  7. Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, South Korea

    Jong Ho Won

  8. Division of Hematology/Oncology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea

    Byeong-Bae Park

  9. Department of Internal Medicine, Dankook University College of Medicine, Cheonan, South Korea

    Soon II Lee

  10. Department of Hematology–Oncology, Asan Medical Center University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea

    Cheolwon Suh

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  1. Sung Yong Oh
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Correspondence to Cheolwon Suh.

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Oh, S.Y., Kim, W.S., Kang, HJ. et al. Treating synchronous bilateral ocular adnexal marginal zone lymphoma: the consortium for improving survival of lymphoma study. Ann Hematol 97, 1851–1857 (2018). https://doi.org/10.1007/s00277-018-3387-5

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