Annals of Hematology

, Volume 97, Issue 9, pp 1735–1736 | Cite as

Mott cell interstitial nephritis revealing Waldenström macroglobulinaemia

  • Anissa Moktefi
  • Caroline Dudreuilh
  • Jean Michel Goujon
  • Nathalie Quellard
  • Jean Marc Zini
  • Vincent Audard
  • Philippe Rémy
Letter to the Editor

Dear Editor,

A 77-year-old man was referred to our department for a recent deterioration of renal function. Relevant medical history included hypertension, type 2 diabetes, and calreticulin-mutated essential thrombocythemia with myelofibrosis. A monoclonal IgM spike, considered to correspond to a monoclonal gammopathy of undetermined significance (MGUS), had been diagnosed 25 years earlier.

Physical examination revealed lower limb edema and isolated splenomegaly without enlarged palpable lymph nodes or peripheral neuropathy. Laboratory investigations revealed an impairment of renal function (creatinine = 170 μmol/L versus 115 μmol/L 2 years ago) associated with marked proteinuria (3.2 g/day) and normal albumin concentration. The patient also exhibited anemia (9.8 g/dl) and thrombocytosis (720,000/mm3) but electrolyte concentrations were normal. Immunoelectrophoresis analysis demonstrated the presence of a circulating monoclonal IgMκ (4 g/L). Immunonephelometric assays confirmed the...


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Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Pathology Department, Groupe Hospitalier Henri-Mondor/Albert ChenevierAPHP (Assistance Publique-Hôpitaux de Paris)CréteilFrance
  2. 2.DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955Université Paris-Est-Créteil, (UPEC)CréteilFrance
  3. 3.Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-ChenevierAP-HP (Assistance Publique-Hôpitaux de Paris)CréteilFrance
  4. 4.Departments of Pathology and Ultrastructural PathologyCHU PoitiersPoitiersFrance
  5. 5.Centre de référence maladies rares amylose AL et autres maladies par dépôts d’immunoglobulines monoclonalesPoitiersFrance
  6. 6.Assistance Publique - Hôpitaux de Paris (AP-HP), Hematology DepartmentSaint Louis HospitalParisFrance

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