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Annals of Hematology

, Volume 97, Issue 6, pp 1111–1113 | Cite as

Acquired long QT syndrome during conditioning for allogeneic stem cell transplantation—are we aware of this side effect?

  • F. Zauner
  • S. Tayeb
  • V. Panagiota
  • M. Rababah
  • A. Ganser
  • M. Eder
  • C. Veltmann
  • Gernot BeutelEmail author
Letter to the Editor

Dear Editor,

Allogeneic stem cell transplantation (SCT) is an established therapy for a broad spectrum of hematologic diseases. Considering comorbidities is crucial for the choice of appropriate conditioning and for the success of SCT. To predict non-relapse mortality and overall survival in patients undergoing SCT, several models like the hematopoietic cell transplantation-specific comorbidity index (HCT-CI) have been developed [1]. While the arrhythmia section of HCT-CI accounts for supra- and ventricular dysrhythmias, QTc prolongation as a risk factor of ventricular arrhythmias and sudden cardiac death has never been addressed. Here, we report a case of an acquired long QT syndrome (ALQTS) developing during FLAMSA-Bu conditioning (fludarabine, cytosine-arabinoside, amasacrine, busulfan, cyclophosphamide) and resulting in torsades de pointes and intrahospital resuscitation [2].

In April 2017, a 65-year-old Caucasian male with secondary acute myeloid leukemia in complete hematological...

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Obtained from the patient included in the study.

Ethical approval

Obtained in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.

References

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • F. Zauner
    • 1
  • S. Tayeb
    • 2
  • V. Panagiota
    • 2
  • M. Rababah
    • 2
  • A. Ganser
    • 2
  • M. Eder
    • 2
  • C. Veltmann
    • 1
  • Gernot Beutel
    • 2
    Email author
  1. 1.Department of Cardiology and AngiologyHannover Medical SchoolHannoverGermany
  2. 2.Department of Hematology, Hemostasis, Oncology and Stem Cell TransplantationHannover Medical SchoolHannoverGermany

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