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Annals of Hematology

, Volume 96, Issue 9, pp 1589–1590 | Cite as

Pregnancy in patients with thrombocytopenia and absent radii (TAR) syndrome

  • Robert T. DiepEmail author
  • Murat O. Arcasoy
Letter to the Editor
  • 177 Downloads

Dear Editor,

Thrombocytopenia and absent radii (TAR) syndrome is a congenital disorder encountered in 1:100,000, characterized by thrombocytopenia due to defective megakaryopoiesis, associated with aplasia of the thin forearm bones, and cardiac abnormalities. Inheritance is autosomal recessive, often resulting from compound heterozygous mutations in RBM8A gene, with rare cases of parent-to-child transmission [ 1, 2, 3]. While the management of prenatal and neonatal TAR syndrome is well documented in the literature, the pregnancy course and the optimal peripartum management of mothers with TAR syndrome are not as defined. There are less than ten reported pregnancies in patients with TAR syndrome in the literature (Table 1). We are writing to discuss a case detailing the hematologic evaluation and management of a primigravid woman with TAR syndrome.
Table 1

Published pregnancies in patients with TAR syndrome [4, 5, 6, 7, 8, 9]

Reference

Pregnancy count

Peripartum management

Mode...

Notes

Compliance with ethical standards

Informed consent

Informed consent was obtained from all patients for being included in the study.

Conflict of interest

The authors declare that they have no conflict of interest.

References

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Department of MedicineDuke University School of MedicineDurhamUSA
  2. 2.Duke University Health System, DUMC 3912DurhamUSA

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