Causes of hospital admission in children and adults with transfusion-dependent thalassemia in Sardinia, 2000–2015
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Since its opening in the 1980s, IIa Clinica Pediatrica at Ospedale Microcitemico “A.Cao” in Cagliari, Italy has been the reference for all types of medical conditions occurring in thalassemia major (TM) patients of all ages from South Sardinia. Between 2000 and 2015, 276 subjects out of 642 (43%) transfused at the same hospital were admitted once or more to IIa Clinica Pediatrica for a total of 690 admissions. The mean age at first hospital admission was 24.3 ± 10.9 years (range 0.2–51 years). At the start of the observation period, all patients followed up at the abovementioned center were on desferrioxamine, with the exception of 21 who were on deferiprone. In December 2015, 15.2% were on desferrioxamine, 25.2% were on deferiprone, 45.4% were on deferasirox, 13.3% were on desferrioxamine plus deferiprone, and 0.8% were on desferrioxamine plus deferasirox.
Over the entire period, the top five most prevalent causes of hospital admission were heart failure and/or...
KeywordsHeart Failure Hospital Admission Thalassemia Lymphadenitis Deferasirox
We would like to address special thanks to Luigia Prontu and Brunella Salis for the precious contribution in acquiring and classifying the hospital discharge forms.
RO and IF designed the research study and wrote the paper. FA analyzed the data. LM gave a substantial contribute to the acquisition of data. MLF, GBL, MM, PM, MP, RAP, VO, CD, and SC contributed to acquiring, analyzing, and interpreting the data. All the authors revised the paper critically and approved the final version.
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Conflict of interest
The authors declare that they have no conflict of interest.