Acute promyelocytic leukaemia is highly frequent among acute myeloid leukaemias in Brazil: a hospital-based cancer registry study from 2001 to 2012
- 259 Downloads
The WHO classification that defines subtypes of acute myeloid leukaemias (AMLs) is relatively unexplored at the population-based level. This study aimed to examine the frequency of acute promyelocytic leukaemia (APL or AML-M3) in Brazil. Data were extracted from 239 cancer centres (2001–2012) and categorized according to the International Classification of Diseases for Oncology (CID-O 3.0) and WHO classification (n = 9116). CID-O3 code 9866 identified 614 APL patients. AML not otherwise specified (NOS) was frequent, and the APL group represented the main subtype specified. The mean age of APL was lower than that of other AMLs (31.5, standard deviation (SD) 18.6 versus 40.9, SD 24.6; p < 0.001); there was a high frequency of APL in the 13–21-year-old (11.8 %) and ≤12.9-year-old (6.4 %) age groups. Time taken to begin treatment (as ≤14 days versus >14 days) and induction death rate were lower in APL than in other AML subtypes (p < 0.001). This report provides additional evidence on the distribution of APL among cases of AML in Brazil.
KeywordsHospital-based study Childhood and adults Acute myeloid leukaemia Acute promyelocytic leukaemia Brazil
MSPO has been supported by FAPERJ #E026/101.562/2010; the project was partially funded by grants from FAPERJ#E026/110.169/2013.
LCT and MSPO contributed equally in the manuscript description.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 9.Swerdlow SH, Campo E, Harris NL et al (2008) WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edn. International Agency for Research on Cancer, LyonGoogle Scholar
- 11.Ferlay J, Bray F, Pisani P, Parkin DM, GLOBOCAN 2002 (2004) Cancer Incidence, Mortality and Prevalence Worldwide, IARC Cancer Base No. 5 Version 2.0. IARC-Press, LyonGoogle Scholar
- 14.Ribeiro RC, Rego E (2006) Management of APL in developing countries: epidemiology, challenges and opportunities for international collaboration. Hematology Am Soc Hematol Educ Program 2006(1):162–168Google Scholar
- 15.Howlader N, Noone AM, Krapcho M et al (2013) SEER Cancer Statistics Review, 1975–2010. National Cancer Institute, BethesdaGoogle Scholar
- 25.Vigitel Brazil 2013 (2014) Protective and risk factors for chronic diseases by telephone survey. Brasilia/DF: Health Minister; URL:http://biavati.files.wordpress.com/2014/05/vigitel-2013.pdf. Accessed 30 Jan 2016