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Annals of Hematology

, Volume 95, Issue 11, pp 1913–1915 | Cite as

Pembrolizumab for relapsed anaplastic large cell lymphoma after allogeneic haematopoietic stem cell transplantation: efficacy and safety

  • Thomas S. Y. Chan
  • Pek-Lan Khong
  • Yok-Lam Kwong
Letter to the Editor

Dear Editor,

Antibody treatment targeting the programmed cell death protein 1 (PD1) is rapidly becoming an important strategy against Hodgkin lymphoma [1]. However, recipients of allogeneic haematopoietic stem cell transplantation (HSCT) are typically excluded from clinical trials. Negative signalling via PD1 after ligation with its ligand PDL1 is regarded to play an important part in ameliorating cytotoxic T cell-mediated graft-versus-host disease (GVHD) [2], implying that PD1 blockade after allogeneic HSCT might incite or exacerbate GVHD.

Notwithstanding these concerns, PD1 blockade has been tested in allogeneic HSCT recipients, which to date is confined to relapsed Hodgkin lymphoma. Two anti-PD1 antibodies nivolumab and pembrolizumab have been used. For nivolumab, in 10 of 14 reported cases who were evaluable [3, 4, 5], 3 patients developed GVHD, 1 case grade IV in severity. Four patients achieved complete response (CR). For pembrolizumab, only three patients have been reported. In...

Keywords

Hodgkin Lymphoma Bendamustine Anaplastic Large Cell Lymphoma Haematopoietic Stem Cell Transplantation Brentuximab Vedotin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors have no acknowledgements to make.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Thomas S. Y. Chan
    • 1
  • Pek-Lan Khong
    • 2
  • Yok-Lam Kwong
    • 1
  1. 1.Department of MedicineQueen Mary HospitalPok Fu LamHong Kong
  2. 2.Department of Diagnostic RadiologyQueen Mary HospitalPok Fu LamHong Kong

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