Annals of Hematology

, Volume 95, Issue 8, pp 1383–1386 | Cite as

Sequential development of chronic myelogenous leukemia and primary myelofibrosis in a patient with history of large B-cell lymphoma treated with radiotherapy and chemotherapy: two myeloid neoplasms with distinct genotypic profiles suggestive of biclonality in a single individual

  • Bin Wu
  • Kimberly Ingersoll
  • Catherine Rehder
  • Siby Sebastian
  • Endi WangEmail author
Letter to the Editor

Dear Editor,

Hematopoietic neoplasms that develop after exposure to cytotoxic agents or therapeutic radiation primarily include myelodysplastic syndrome (MDS), myelodysplastic/myeloproliferative neoplasm (MDS/MPN), and acute myeloid leukemia (AML) [1]. Although much less frequently encountered, therapy-related B-lymphoblastic leukemia has also been reported in the literature [2]. Myeloproliferative neoplasm (MPN) arising as a therapy-related malignancy is exceedingly rare [1], and its pathogenesis has not been well characterized, particularly in relation to chemotherapeutic agents. Here, we report a case with the sequential development of biclonal MPNs; the patient initially developed chronic myelogenous leukemia (CML) and subsequently developed primary myelofibrosis (PMF) following the treatment for diffuse large B-cell lymphoma (DLBCL).

48-year-old Caucasian male was diagnosed with DLBCL in a left epitrochlear lymph node and was initially stage IA. He received local radiotherapy and...


Chronic Myelogenous Leukemia Nilotinib Polycythemia Vera Ruxolitinib Jak2 V617F Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank Steven Conlon in the Department of Pathology at Duke University Medical Center for the technical assistance of photo images and figure illustration.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Financial disclosure

None reported.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Bin Wu
    • 1
    • 2
  • Kimberly Ingersoll
    • 2
  • Catherine Rehder
    • 2
  • Siby Sebastian
    • 2
  • Endi Wang
    • 2
    • 3
    Email author
  1. 1.Division of Hematology, Department of MedicineShengjing Hospital affiliated with China Medical UniversityShenyangPeople’s Republic of China
  2. 2.Department of PathologyDuke University Medical CenterDurhamUSA
  3. 3.Department of PathologyDurhamUSA

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