Sequential development of chronic myelogenous leukemia and primary myelofibrosis in a patient with history of large B-cell lymphoma treated with radiotherapy and chemotherapy: two myeloid neoplasms with distinct genotypic profiles suggestive of biclonality in a single individual
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Hematopoietic neoplasms that develop after exposure to cytotoxic agents or therapeutic radiation primarily include myelodysplastic syndrome (MDS), myelodysplastic/myeloproliferative neoplasm (MDS/MPN), and acute myeloid leukemia (AML) . Although much less frequently encountered, therapy-related B-lymphoblastic leukemia has also been reported in the literature . Myeloproliferative neoplasm (MPN) arising as a therapy-related malignancy is exceedingly rare , and its pathogenesis has not been well characterized, particularly in relation to chemotherapeutic agents. Here, we report a case with the sequential development of biclonal MPNs; the patient initially developed chronic myelogenous leukemia (CML) and subsequently developed primary myelofibrosis (PMF) following the treatment for diffuse large B-cell lymphoma (DLBCL).
KeywordsChronic Myelogenous Leukemia Nilotinib Polycythemia Vera Ruxolitinib Jak2 V617F Mutation
We thank Steven Conlon in the Department of Pathology at Duke University Medical Center for the technical assistance of photo images and figure illustration.
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Conflict of interest
The authors declare that they have no conflict of interest.