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Annals of Hematology

, Volume 95, Issue 5, pp 719–732 | Cite as

Current opinion and consensus statement regarding the diagnosis, prognosis, and treatment of patients with essential thrombocythemia: a survey of the Spanish Group of Ph-negative Myeloproliferative Neoplasms (GEMFIN) using the Delphi method

  • C. BessesEmail author
  • J. C. Hernández-Boluda
  • M. Pérez Encinas
  • J. M. Raya
  • J. M. Hernández-Rivas
  • A. Jiménez Velasco
  • J. Martínez Lopez
  • V. Vicente
  • C. Burgaleta
  • on behalf of GEMFIN
Original Article

Abstract

The current consensus on the diagnosis, prognosis, and treatment of essential thrombocythemia (ET) is based on experts’ recommendations. However, several aspects of the diagnosis of, prognosis of, and therapy for ET are still controversial. The Delphi method was employed with an expert panel of members of the Spanish Group of Ph-negative Myeloproliferative Neoplasms in order to identify the degree of agreement on the diagnosis, prognosis, and treatment of ET. Nine leading experts selected a total of 41 clinical hematologists with well-known expertise in ET. An electronic questionnaire was used to collect the questions rated in a four-step scale. The questions were grouped into four blocks: diagnosis, risk stratification, goals of therapy, and treatment strategy. After the first round consisting of 80 questions, a second round including 14 additional questions focused on the recommendations advocated by experts of the European LeukemiaNet in 2011 was analyzed. The median and mean values for the first and second rounds were calculated. A summary of the conclusions considered as the most representative of each block of questions is presented. The Delphi method is a powerful instrument to address the current approaches and controversies surrounding ET.

Keywords

Essential thrombocythemia Delphi Consensus statement Survey questionnaire 

Notes

Acknowledgments

We are indebted to all members of GEMFIN who participated in this study.

This work was supported by grants PI13/00393, PI13/00557, and RD12/0036/0010 from the Instituto de Salud Carlos III; SGR 2014-567; and funding from Shire Pharmaceuticals Ibérica for the conduct of this study.

The authors are grateful to the physicians who kindly participated in the expert panel: Anna Angona, Hospital del Mar, Barcelona; Maria Luisa Antelo, Hospital de Navarra, Navarra; Elisa Arbelo, Hospital Virgen de Macarena, Sevilla; Ana Isabel Arribas, Hospital de la Axarquia, Málaga, and Inmaculada Ballesteros Hospital de la Axarquia, Málaga; Concepción Boqué, Hospital Universitario de Bellvitge, Barcelona; Gonzalo Caballero, Hospital Universitario Miguel Servet, Zaragoza; Dolores Fernandez, Hospital Clínico San Cecilio, Granada; Carlos Fernandez, Hospital Materno Infantil; Teresa Herrera, A Coruña; J. Valentín Garcia, Hospital Ramón y Cajal, Madrid; Montse Gómez, Hospital Quirón de Valencia, Valencia; Maria Teresa Gómez Casares, Hospital Dr. Negrín, Canarias; Jose Julio Hernandez, Hospital de San Eloy, Vizcaya; Juan Carlos Hernandez, Hospital Quirón Valencia, Valencia; Ana Jimenez, Hospital 12 de Octubre, Madrid; Ana Kerguelen, Hospital Universitario La Paz, Madrid; Elisa Luño, Hospital Universitario Central de Asturias, Asturias; Joaquín Martinez López, Hospital 12 de Octubre; María Isabel Mata, Hospital Costa del Sol, Málaga; Antonio Paz Coll, Hospital Puerto Real, Cádiz; Maria Jose Ramírez, Hospital de Jerez de la Frontera, Cádiz; Juan Nicolás Rodriguez, Hospital Juan Ramón Jimenez, Huelva; Adriana Simiele, Hospital Povisa, Pontevedra; Antonio Cervero, Hospital General Universitario de Valencia, Valencia; Jesús Maria Cesar, Hospital Ramón y Cajal, Madrid; Natalia de las Heras, Hospital Universitario de León; Margarita Fernandez de la Mata, Hospital Universitario Reina Sofía, Córdoba; Mar Hermosilla, Hospital San Pedro, Rioja; Esperanza Lavilla, Hospital Lucus Augusti, Lugo; Carmen Loureiro, Hospital do Meixoeiro, Pontevedra; Elena Magro, Hospital Príncipe de Asturias, Madrid; Sergio Ortegón, Hospital General de Llorena, Badajoz; Maria Antonia Peñalver, Hospital Universitario Severo Ochoa, Madrid; Maria Angeles Pérez, Hospital Fundación Jimenez Díaz, Madrid; and Maria del Carmen Santo, Hospital Central de Asturias, Asturias.

Authors’ contributions

Carlos Besses designed the study, collected the data, analyzed and interpreted the results, and wrote the paper; Juan Carlos Hernández-Boluda collected the data, analyzed and interpreted the results, and wrote the paper; Manuel Pérez Encinas collected the data, analyzed and interpreted the results, and approved the final version; José María Raya collected the data, analyzed and interpreted the results, and approved the final version; Jesús María Hernández-Rivas collected the data, analyzed and interpreted the results, and approved the final version; Antonio Jiménez Velasco collected the data, analyzed and interpreted the results, and approved the final version; Joaquín Martínez López collected the data, analyzed and interpreted the results, and approved the final version; Vicente Vicente collected the data, analyzed and interpreted the results, and approved the final version; and Carmen Burgaleta designed the study, collected the data, analyzed and interpreted the results, and approved the final version.

Compliance with ethical standards

Conflict of interest

Carlos Besses, Vicente Vicente, and Carmen Burgaleta received honoraria from Shire for speaking at symposia.

Supplementary material

277_2016_2614_MOESM1_ESM.doc (650 kb)
Table S1 (DOC 650 kb)
277_2016_2614_MOESM2_ESM.doc (86 kb)
Table S2 (DOC 86 kb)
277_2016_2614_MOESM3_ESM.doc (77 kb)
Table S3 (DOC 77 kb)
277_2016_2614_MOESM4_ESM.doc (114 kb)
Table S4 (DOC 113 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • C. Besses
    • 1
    Email author
  • J. C. Hernández-Boluda
    • 2
  • M. Pérez Encinas
    • 3
  • J. M. Raya
    • 4
  • J. M. Hernández-Rivas
    • 5
  • A. Jiménez Velasco
    • 6
  • J. Martínez Lopez
    • 7
  • V. Vicente
    • 8
  • C. Burgaleta
    • 9
  • on behalf of GEMFIN
  1. 1.Hematology DepartmentHospital del MarBarcelonaSpain
  2. 2.Hematology DepartmentHospital ClínicoValenciaSpain
  3. 3.Hematology DepartmentHospital ClínicoSantiago de CompostelaSpain
  4. 4.Hematology DepartmentHospital Universitario de CanariasTenerifeSpain
  5. 5.Hematology DepartmentHospital Universitario de SalamancaSalamancaSpain
  6. 6.Hematology DepartmentHospital Regional UniversitarioMálagaSpain
  7. 7.Hematology DepartmentHospital 12 de OctubreMadridSpain
  8. 8.Hematology DepartmentHospital Morales MesseguerMurciaSpain
  9. 9.Hematology DepartmentHospital Príncipe de AsturiasAlcalá de HenaresSpain

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