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Annals of Hematology

, Volume 95, Issue 3, pp 523–524 | Cite as

Remission of remitting seronegative symmetrical synovitis with pitting edema after unrelated cord blood transplantation for myelodysplastic syndrome

  • Hiroto Ishii
  • Takaaki KonumaEmail author
  • Kei Ohnuma
  • Osamu Hosono
  • Hirotoshi Tanaka
  • Seiko Kato
  • Arinobu Tojo
  • Satoshi Takahashi
Letter to the Editor

Dear Editor,

Allogeneic hematopoietic stem cell transplantation (HSCT) has been reported to induce remission of coincidental or sole autoimmune disease [1, 2, 3]. We report on a patient with myelodysplastic syndrome (MDS) whose remitting seronegative symmetrical synovitis with pitting edema (RS3PE) achieved remission without any treatment after unrelated cord blood transplantation (CBT).

A 60-year-old man with a two-month history of morning stiffness in the hand joints, polyarthralgia, and edema of the dorsum of both the hands and feet was admitted to our hospital. Laboratory findings revealed an elevated matrix metalloproteinaise-3 (MMP-3) of 824.1 ng/mL (<121), along with macrocytic anemia. Rheumatoid factor, antinuclear antibody, and anti-cyclic citrullinated peptide antibody were negative. Magnetic resonance imaging (MRI) of the hands demonstrated soft tissue swelling without bone erosion. Based on these data, he was diagnosed with RS3PE. Bone marrow examination revealed dysplasia...

Keywords

Atopic Dermatitis Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation Azacitidine Refractory Anemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Hiroto Ishii
    • 1
  • Takaaki Konuma
    • 1
    Email author
  • Kei Ohnuma
    • 2
  • Osamu Hosono
    • 3
  • Hirotoshi Tanaka
    • 3
    • 4
  • Seiko Kato
    • 1
  • Arinobu Tojo
    • 1
  • Satoshi Takahashi
    • 1
  1. 1.Department of Hematology/Oncology, The Institute of Medical ScienceThe University of TokyoMinato-kuJapan
  2. 2.Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of MedicineJuntendo UniversityTokyoJapan
  3. 3.Department of Rheumatology and Allergy, The Institute of Medical ScienceThe University of TokyoTokyoJapan
  4. 4.Division of Rheumatology, Center for Antibody and Vaccine, The Institute of Medical ScienceThe University of TokyoTokyoJapan

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