Annals of Hematology

, Volume 94, Issue 11, pp 1839–1843 | Cite as

Outcome of patients with primary refractory diffuse large B cell lymphoma after R-CHOP treatment

  • Felicitas Hitz
  • J. M. Connors
  • R. D. Gascoyne
  • P. Hoskins
  • A. Moccia
  • K. J. Savage
  • L. H. Sehn
  • T. Shenkier
  • D. Villa
  • R. Klasa
Original Article

Abstract

Primary refractory diffuse large B cell lymphoma (DLBCL) following R-CHOP chemotherapy is a major concern. We identified 1126 patients with DLBCL treated with R-CHOP from 2000 to 2009, of whom 166 (15 %) had primary refractory disease. Of the 75/166 (45 %) who were age <70 years and had been planned for stage-directed curative therapy, 43 (57 %) were primary nonresponders and 32 (43 %) relapsed within 3 months of completing R-CHOP. Thirty of 75 (40 %) patients had serious comorbidity and organ dysfunction precluding intensive treatment and had palliative treatment only. Twelve of 45 (27 %) patients responded to second-line treatment and underwent ASCT. The median overall survival for the 75 patients was 10 months with only seven patients alive without evidence of disease at follow-up ranging from 14 to 106 months. Primary refractory DLBCL after R-CHOP has a very poor outcome with only anecdotal survivors independent of the intended treatment approach.

Keywords

Primary refractory Diffuse large B cell lymphoma R-CHOP Comorbidity 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Felicitas Hitz
    • 1
    • 2
    • 4
  • J. M. Connors
    • 2
  • R. D. Gascoyne
    • 2
    • 3
  • P. Hoskins
    • 2
  • A. Moccia
    • 2
    • 4
  • K. J. Savage
    • 2
  • L. H. Sehn
    • 2
  • T. Shenkier
    • 2
  • D. Villa
    • 2
  • R. Klasa
    • 2
  1. 1.Medical Oncology, Oncology/HaematologyKantonsspital St. GallenSt. GallenSwitzerland
  2. 2.British Columbia Cancer Agency Centre for Lymphoid CancerVancouverCanada
  3. 3.Division of PathologyBritish Columbia Cancer Agency and the University of British ColumbiaVancouverCanada
  4. 4.Istituto Oncologico della Svizzera ItalianaBellinzonaSwitzerland

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