Annals of Hematology

, Volume 94, Issue 11, pp 1927–1928 | Cite as

Efficacy of ruxolitinib in myeloid neoplasms with PCM1-JAK2 fusion gene

  • Elisa Rumi
  • Jelena D. Milosevic
  • Dominik Selleslag
  • Ilaria Casetti
  • Els Lierman
  • Daniela Pietra
  • Chiara Cavalloni
  • Marta Bellini
  • Chiara Milanesi
  • Irene Dambruoso
  • Cesare Astori
  • Robert Kralovics
  • Peter Vandenberghe
  • Mario Cazzola
Letter to the Editor

Notes

Acknowledgements

The study was supported by grants from Associazione Italiana per la Ricerca sul Cancro (AIRC) (Special Program “Molecular Clinical Oncology 5 per mille” AGIMM-AIRC Gruppo Italiano Malattie Mieloproliferative- project no. 1005 to MC, and my first AIRC grant MFAG project 15672 to ER) and by a grant form Italian Ministry of Health (GR-2010-2312855) to ER. A special thank to Dr. Laura Tassi and Prof. Giorgio Lo Russo for their technical support.

Conflict of interest

The authors do not have potential conflicts of interest related to this paper.

References

  1. 1.
    Schwaab J, Knut M, Haferlach C, Metzgeroth G, Horny HP, Chase A, Tapper W, Score J, Waghorn K, Naumann N, Jawhar M, Fabarius A, Hofmann WK, Cross NC, Reiter A (2015) Limited duration of complete remission on ruxolitinib in myeloid neoplasms with PCM1-JAK2 and BCR-JAK2 fusion genes. Ann Hematol 94(2):233–8CrossRefPubMedGoogle Scholar
  2. 2.
    Lierman E, Selleslag D, Smits S, Billiet J, Vandenberghe P (2012) Ruxolitinib inhibits transforming JAK2 fusion proteins in vitro and induces complete cytogenetic remission in t(8;9)(p22;p24)/PCM1-JAK2-positive chronic eosinophilic leukemia. Blood 120(7):1529–31CrossRefPubMedGoogle Scholar
  3. 3.
    Rumi E, Milosevic JD, Casetti I, Dambruoso I, Pietra D, Boveri E, Boni M, Bernasconi P, Passamonti F, Kralovics R, Cazzola M (2013) Efficacy of ruxolitinib in chronic eosinophilic leukemia associated with a PCM1-JAK2 fusion gene. J Clin Oncol 31(17):e269–71CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Elisa Rumi
    • 1
  • Jelena D. Milosevic
    • 2
  • Dominik Selleslag
    • 3
  • Ilaria Casetti
    • 4
  • Els Lierman
    • 5
  • Daniela Pietra
    • 1
  • Chiara Cavalloni
    • 4
  • Marta Bellini
    • 4
  • Chiara Milanesi
    • 1
  • Irene Dambruoso
    • 1
  • Cesare Astori
    • 1
  • Robert Kralovics
    • 2
    • 6
  • Peter Vandenberghe
    • 5
  • Mario Cazzola
    • 1
    • 4
  1. 1.Department of Hematology OncologyFondazione IRCCS Policlinico San MatteoPaviaItaly
  2. 2.CeMM Research Center for Molecular Medicine of the Austrian Academy of SciencesViennaAustria
  3. 3.AZ Sint-JanBruggeBelgium
  4. 4.Department of Molecular MedicineUniversity of PaviaPaviaItaly
  5. 5.Center for Human GeneticsKU Leuven/University Hospital LeuvenLeuvenBelgium
  6. 6.Department of Internal Medicine I, Division of Hematology and Blood CoagulationMedical University of ViennaViennaAustria

Personalised recommendations