Deletion of SPRY4 is a frequent event in secondary acute myeloid leukemia
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KeywordsAcute Myeloid Leukemia TP53 Mutation Myeloproliferative Neoplasm Pathway Mutation Copy Number Loss
This work was supported by the Austrian Science Fund under Grant No. P 26619-B19 (to AZ). Work in the laboratories of AW, HS, and AZ is further supported by Leukämiehilfe Steiermark.
Conflict of Interest
The authors declare that they have no conflict of interest.
Ethical approval and informed consent
This study was approved by the institutional review board of the Medical University of Graz, Austria, and was conducted in accordance with the Declaration of Helsinki. Informed consent was obtained from all individual participants included in this study.
OG and SH carried out the qPCR experiments, analyzed the data, and drafted the manuscript. KK and GH carried out NGS experiments, analyzed the data, and drafted the manuscript. AW and AZ reviewed the clinical data, performed statistical analyses, and drafted the manuscript. HS and AZ designed the study, analyzed the data and drafted the manuscript. All authors read and approved the final typescript.