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Immune thrombocytopenia: epidemiological and clinical features of 216 patients in northwestern Turkey

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Abstract

We evaluated the clinical features, treatment modalities, treatment responses, and prognosis of our patients with immune thrombocytopenia (ITP). Furthermore, we estimated the frequency of ITP in the Thrace region of Turkey. Two hundred sixteen patients diagnosed with ITP between 2000 and 2012 at our center were retrospectively evaluated. Patients’ clinical features, treatments, and responses to treatment modalities were recorded. The mean annual incidence of ITP was 2.92/100,000 (95%CI: 1.57–4.27). The overall prevalence of ITP was 35.1/100,000 (95%CI: 30.3–39.8). The administration of first-line therapy resulted in complete remission (CR) in 76.5 % of patients and partial remission (PR) in 13.6 %. After 5 years, 33 % of patients who were responsive to first-line therapy were still in relapse-free remission. Of patients who were given second-line therapy, CR was obtained in 71.3 % and PR in 14.9 %. The duration of relapse-free remission was longer with splenectomy than with steroids (p < 0.001). Five years after splenectomy, 62 % of patients were in relapse-free remission; contrarily, this was lower with steroids (36 % at 5 years). The annual incidence and prevalence of ITP in northwestern Turkey was similar to data from western countries—at the lower limit for some countries. Effective treatment strategies seem to be steroids as first-line therapy and splenectomy in refractory cases.

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The authors declare no conflicts of interest for this manuscript.

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Written informed consent was given by all subjects in this study.

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Authors and Affiliations

  1. Department of Internal Medicine, Trakya University Medical Faculty, Edirne, Turkey

    Ahmet Koylu

  2. Department of Hematology, Trakya University Medical Faculty, Edirne, Turkey

    Gulsum Emel Pamuk, Mehmet Sevki Uyanik & Muzaffer Demir

  3. Department of Rheumatology, Trakya University Medical Faculty, Edirne, Turkey

    Omer Nuri Pamuk

  4. Eski Yildiz Cad. Park Apt. No:22 Daire: 18, 34349, Besiktas, Istanbul, Turkey

    Gulsum Emel Pamuk

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  1. Ahmet Koylu
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  2. Gulsum Emel Pamuk
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  4. Muzaffer Demir
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Correspondence to Gulsum Emel Pamuk.

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Koylu, A., Pamuk, G.E., Uyanik, M.S. et al. Immune thrombocytopenia: epidemiological and clinical features of 216 patients in northwestern Turkey. Ann Hematol 94, 459–466 (2015). https://doi.org/10.1007/s00277-014-2220-z

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  • DOI: https://doi.org/10.1007/s00277-014-2220-z

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