Annals of Hematology

, Volume 94, Issue 3, pp 409–414 | Cite as

Prognostic impact of intraocular involvement in primary CNS lymphoma: experience from the G-PCNSL-SG1 trial

  • Stephan Kreher
  • Felicitas Strehlow
  • Peter Martus
  • Patrick Roth
  • Bernd Hertenstein
  • Alexander Röth
  • Tobias Birnbaum
  • Frank Griesinger
  • Michael Rauch
  • Lothar Kanz
  • Eckhard Thiel
  • Michael Weller
  • Agnieszka Korfel
Original Article

Abstract

The impact of intraocular involvement (IOL) in primary CNS lymphoma (PCNSL) has not been sufficiently evaluated. Here, we present the analysis of IOL in the only completed randomized phase III trial in PCNSL. The G-PCNSL-SG1 study evaluated the role of whole-brain radiotherapy in primary therapy of PCNSL. Data of the 526 eligible study patients were checked, and clinical characteristics, therapy, and outcome of patients with IOL diagnosed at study inclusion were analyzed. Ophthalmologic examination at study inclusion was performed in 297 patients (56.5 %) of whom IOL was diagnosed in 19 (6.4 %). Clinical characteristics did not significantly differ between patients with IOL (IOL+) and those without (IOL−). The median progression-free survival (PFS) in the IOL+ group was 3.5 months (95 % CI 0.0–7.07) as compared to 8.3 months (95 % CI 4.78–11.78) in the IOL− group (P = 0.004), the median overall survival (OS) was 13.2 months (95 % CI 0.86–25.62) and 20.5 months (95 % CI 15.56–25.5), respectively (P = 0.155). In multivariate analysis, a significantly inferior PFS and OS for IOL+ patients were found. IOL at diagnosis of PCNSL was an independent negative prognostic indicator for PFS and OS in this analysis.

Keywords

Intraocular lymphoma Primary CNS lymphoma Progression-free survival Overall survival 

Notes

Conflict of interest

MW, ET, and AK were the principal investigators; PR, BH, AR, TB, FG, MR, MW, ET, and AK contributed patients to the trial; PM did the statistical analyses; SK, FS, and AK wrote the report; and all authors approved the report. The authors report no potential conflicts of interest.

Supplementary material

277_2014_2212_MOESM1_ESM.doc (40 kb)
Supplementary Table 1 (DOC 40 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Stephan Kreher
    • 1
  • Felicitas Strehlow
    • 1
  • Peter Martus
    • 2
  • Patrick Roth
    • 3
  • Bernd Hertenstein
    • 4
  • Alexander Röth
    • 5
  • Tobias Birnbaum
    • 6
  • Frank Griesinger
    • 7
  • Michael Rauch
    • 8
  • Lothar Kanz
    • 9
  • Eckhard Thiel
    • 1
  • Michael Weller
    • 3
  • Agnieszka Korfel
    • 1
  1. 1.Department of Hematology & OncologyCampus Benjamin FranklinBerlinGermany
  2. 2.Institute of Clinical Epidemiology and Applied BiostatisticsUniversity TuebingenTuebingenGermany
  3. 3.Department of NeurologyUniversity Hospital ZurichZurichSwitzerland
  4. 4.Department of Hematology & OncologyKlinikum Bremen MitteBremenGermany
  5. 5.Department of Hematology, West German Cancer CenterUniversity Hospital EssenEssenGermany
  6. 6.Department of NeurologyUniversity Hospital GrosshadernMunichGermany
  7. 7.Department of Radiotherapy and Medical OncologyPius Hospital OldenburgOldenburgGermany
  8. 8.Department of Hematology & OncologyEvangelisches Krankenhaus BielefeldBielefeldGermany
  9. 9.University Department of Medicine, Department of Internal MedicineUniversity Hospital TuebingenTuebingenGermany

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