Sleep problems and psychological distress in family members of patients with hematological malignancies in the Japanese population
- 225 Downloads
Patients with cancer frequently suffer from insomnia symptoms, and additionally, their family members also often experience these symptoms. The aim of this study was to investigate the prevalence of insomnia symptoms in both family members and patients with hematological malignancies. We conducted an observational cross-sectional study using a clinical self-reported questionnaire for sleep conditions, depressive symptoms (two-question method), and worries (five items that originated from the Brief Cancer Worry Inventory). One hundred twelve family members and 153 patients were investigated. A t test and Chi-square test were used to compare the prevalence of insomnia and depressive symptoms between family members and patients. Logistic regression was used to determine whether insomnia symptoms or worries related to patients’ disease had an impact on depressive symptoms. The presence of insomnia symptoms in family members (87 %) was significantly higher than that in patients (60 %, p < 0.001). The prevalence of depressive mood and anhedonia in family members were 55 and 34 %, respectively, and these values were higher than those in patients (43 and 28 %, respectively). Insomnia symptoms and worries about present/prospective disease conditions were significantly associated with depressive mood (insomnia symptoms, odds ratios (OR) 4.3, confidence intervals (CI) 1.2–15.2, p = 0.025; worries, OR 4.4, CI 1.0–19.3, p = 0.048). Taken together, our results demonstrated that insomnia symptoms and depressive symptoms are highly prevalent in family members as well as in patients with hematological malignancies.
KeywordsHematological malignancy Family member Insomnia Depressive symptom Worry
We would like to thank to Ms. Akiko Hashimoto and the Japanese patient advocacy group of hematological malignancies “Tsubasa” for supporting our questionnaire research.
Conflict of interest
The authors declare that they have no conflict of interest.
- 10.Berger AM, Mitchell SA (2008) Modifying cancer-related fatigue by optimizing sleep quality. J Natl Compr Cancer Netw 6(1):3–13Google Scholar
- 26.Mitchell AJ, Chan M, Bhatti H, Halton M, Grassi L, Johansen C, Meader N (2011) Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. Lancet Oncol 12(2):160–174. doi: 10.1016/S1470-2045(11)70002-X PubMedCrossRefGoogle Scholar
- 27.Baglioni C, Battagliese G, Feige B, Spiegelhalder K, Nissen C, Voderholzer U, Lombardo C, Riemann D (2011) Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord 135(1–3):10–19. doi: 10.1016/j.jad.2011.01.011 PubMedCrossRefGoogle Scholar
- 32.American Psychiatric Association, American Psychiatric Association. Task Force on DSM-IV (1994) Diagnostic and statistical manual of mental disorders: DSM-IV, 4th edn. American Psychiatric Association, Washington, DCGoogle Scholar
- 38.Portenoy RK, Thaler HT, Kornblith AB, Lepore JM, Friedlander-Klar H, Kiyasu E, Sobel K, Coyle N, Kemeny N, Norton L et al (1994) The Memorial Symptom Assessment Scale: an instrument for the evaluation of symptom prevalence, characteristics and distress. Eur J Cancer 30A(9):1326–1336PubMedCrossRefGoogle Scholar
- 39.Chang VT, Hwang SS, Feuerman M, Kasimis BS, Thaler HT (2000) The Memorial Symptom Assessment Scale Short Form (MSAS-SF). Cancer 89(5):1162–1171. doi: 10.1002/1097-0142(20000901)89:5<1162::AID-CNCR26>3.0.CO;2-Y PubMedCrossRefGoogle Scholar
- 41.Carney S, Koetters T, Cho M, West C, Paul SM, Dunn L, Aouizerat BE, Dodd M, Cooper B, Lee K, Wara W, Swift P, Miaskowski C (2011) Differences in sleep disturbance parameters between oncology outpatients and their family caregivers. J Clin Oncol 29(8):1001–1006. doi: 10.1200/JCO.2010.30.9104 PubMedCentralPubMedCrossRefGoogle Scholar
- 44.Mitchell AJ, Meader N, Davies E, Clover K, Carter GL, Loscalzo MJ, Linden W, Grassi L, Johansen C, Carlson LE, Zabora J (2012) Meta-analysis of screening and case finding tools for depression in cancer: evidence based recommendations for clinical practice on behalf of the Depression in Cancer Care consensus group. J Affect Disord 140(2):149–160. doi: 10.1016/j.jad.2011.12.043 PubMedCrossRefGoogle Scholar
- 45.Fujisawa D, Park S, Kimura R, Suyama I, Koyama Y, Takeuchi M, Yoshikawa H, Hashiguchi S, Shirahase J, Kato M, Takeda J, Kashima H (2010) Unmet supportive needs of cancer patients in an acute care hospital in Japan–a census study. Support Care Cancer 18(11):1393–1403. doi: 10.1007/s00520-009-0761-9 PubMedCrossRefGoogle Scholar