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Annals of Hematology

, Volume 93, Issue 1, pp 113–121 | Cite as

Lenalidomide with dexamethasone treatment for relapsed/refractory myeloma patients in Korea—experience from 110 patients

  • Kihyun KimEmail author
  • Seok Jin Kim
  • Verena Voelter
  • Cheolwon Suh
  • Sung-Soo Yoon
  • Je-Jung Lee
  • Jae-Yong Kwak
  • Hun-Mo Ryoo
  • Yang Soo Kim
  • Joon Ho Moon
  • Seong Kyu Park
  • Sung-Hyun Kim
  • Yeung-Chul Mun
  • Jin Seok Kim
  • Hyeon-Seok Eom
  • Deog-Yeon Jo
  • Hyun Jung Jun
  • Ki-Hwan Kim
  • Jeong-Ok Lee
  • Jae Hoon Lee
  • Chang-Ki MinEmail author
  • Korean Multiple Myeloma Working Party (KMMWP)
Original Article

Abstract

We conducted a retrospective analysis of lenalidomide with dexamethasone for patients with relapsed/refractory multiple myeloma (RRMM) who were treated within the Korean patient access program. Lenalidomide has been approved for RRMM for several years in Europe and North America, but has not been accessible to Asian patients in the past. Between 2008 and 2012, 110 patients from 20 hospitals were enrolled. The overall response rate (ORR) was 43.6 % with 15.4 % of very good partial response (VGPR) or better. The median time to progression (TTP) in this heavily pretreated patient population was 8.0 months, and median overall survival (OS) was 23 months. Hematologic toxicities, fatigue, anorexia, and constipation were the most common adverse events. The number of previous treatment lines, previous exposure to thalidomide, refractoriness to thalidomide and bortezomib, pretreatment white blood cell count (WBC), platelet count, t(14;16), and 17p deletion were significant prognostic factors for TTP, and creatinine clearance, refractoriness to thalidomide and bortezomib, performance status, platelet count, and 17p deletion were significant for OS in univariate analysis. In multivariate analysis, WBC and platelet count were significant prognostic factors for TTP and performance status for OS. For Korean myeloma patients, lenalidomide showed considerable efficacy, and toxicities were comparable to the data published in Europe and North America.

Keywords

Lenalidomide Relapsed myeloma Korean 

Notes

Acknowledgments

KK, SJK, VV, CS, S-SY, J-JL, J-YK, H-MR, YSK, JHM, SKP, S-HK, Y-CM, JSK, H-SE, D-YJ, HJJ, K-HK, J-OL, JHK, and C-KM performed the research; KK, S-SY, and C-KM designed the research; CS, C-KM, and J-JL contributed essential reagents or tools; KK analyzed the data; and KK, SJK, and VV wrote the paper.

Conflict of interest

VV is an employee of Celgene Corporation. The other writers have no conflicts of interests.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Kihyun Kim
    • 1
    Email author
  • Seok Jin Kim
    • 1
  • Verena Voelter
    • 2
  • Cheolwon Suh
    • 3
  • Sung-Soo Yoon
    • 4
  • Je-Jung Lee
    • 5
  • Jae-Yong Kwak
    • 6
  • Hun-Mo Ryoo
    • 7
  • Yang Soo Kim
    • 8
  • Joon Ho Moon
    • 9
  • Seong Kyu Park
    • 10
  • Sung-Hyun Kim
    • 11
  • Yeung-Chul Mun
    • 12
  • Jin Seok Kim
    • 13
  • Hyeon-Seok Eom
    • 14
  • Deog-Yeon Jo
    • 15
  • Hyun Jung Jun
    • 16
  • Ki-Hwan Kim
    • 17
  • Jeong-Ok Lee
    • 18
  • Jae Hoon Lee
    • 19
  • Chang-Ki Min
    • 20
    Email author
  • Korean Multiple Myeloma Working Party (KMMWP)
  1. 1.Division of Hematology-Oncology, Department of MedicineSamsung Medical Center, Sungkyunkwan University School of MedicineSeoulSouth Korea
  2. 2.Celgene KoreaSeoulSouth Korea
  3. 3.Department of OncologyAsan Medical Center, University of Ulsan College of MedicineSeoulSouth Korea
  4. 4.Department of Internal MedicineSeoul National University HospitalSeoulSouth Korea
  5. 5.Department of Hematology-OncologyChonnam National University Hwasun HospitalHwasunSouth Korea
  6. 6.Department of Internal MedicineChonbuk National University Medical SchoolJeonjuSouth Korea
  7. 7.Department of Internal MedicineDaegu Catholic University Medical CenterDaeguSouth Korea
  8. 8.Department of Internal MedicineKosin University Gospel HospitalBusanSouth Korea
  9. 9.Department of Internal MedicineKyungpook National University HospitalDaeguSouth Korea
  10. 10.Department of Internal medicineSoonchunhyang University Bucheon HospitalBucheonSouth Korea
  11. 11.Department of Internal MedicineDong-A University College of MedicineBusanSouth Korea
  12. 12.Department of Internal MedicineEwha Womans University School of MedicineSeoulSouth Korea
  13. 13.Division of Hematology, Department of Internal MedicineYonsei University College of MedicineSeoulSouth Korea
  14. 14.Hematology-Oncology Clinic, National Cancer CenterGoyang-siSouth Korea
  15. 15.Department of Internal MedicineChungnam National University Hospital, Chungnam National University College of MedicineDaejeonSouth Korea
  16. 16.Medical Oncology and Hematology, Department of Internal MedicineSeoul Medical CenterSeoulSouth Korea
  17. 17.Department of Internal MedicineSeoul National University Boramae HospitalSeoulSouth Korea
  18. 18.Department of Internal MedicineSeoul National University Bundang HospitalSeongnamSouth Korea
  19. 19.Department of Internal MedicineGachon University Gil HospitalIncheonSouth Korea
  20. 20.Division of Hematology, Department of Internal MedicineSeoul St. Mary’s Hospital, The Catholic University of KoreaSeoulSouth Korea

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