MLL-AF9 rearrangement in myeloid sarcomas involving the breast
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A 29-year-old woman (patient 1) presented to our facility in August 2011 for migrating arthralgia at bilateral elbow and knee joints. CT scan revealed coarse articular surface of bilateral sacroiliac joints with slight irregularity. Serological tests for autoantibodies were all negative. Three months later, palpable masses were sequentially reported at the left and right breast. Fine needle biopsy of the left breast indicated malignancy with hematopoietic origin. Bone marrow aspiration revealed acute myeloid leukemia with FAB AML-M4 morphology. Flow cytometric study showed 21 % malignant cells of marrow sample, which had an expression of surface markers including CD117, CD33, CD38, CD15, CD64, CD4, and CD56. Malignant cells possessed a recurrent cytogenetic aberration shown by G-banding as 47, XX, + 8, t(9;11)(p22;q23). Further molecular surveys confirmed the existence of an MLL-AF9 fusion gene. Patient 2 was a 28-year-old woman who presented to our facility in October...
KeywordsAcute Myeloid Leukemia Idarubicin Bone Marrow Aspiration Fine Needle Biopsy Bone Marrow Lesion
Conflict of interest
None of the contributors have any potential conflicts of interest.
- 1.Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (2008) WHO classification of tumors of haematopoietic and lymphoid tissues. IARC, Lyon, pp 140–141Google Scholar
- 6.Pileri SA, Ascani S, Cox MC, Campidelli C, Bacci F, Piccioli M, Piccaluga PP, Agostinelli C, Asioli S, Novero D, Bisceglia M, Ponzoni M, Gentile A, Rinaldi P, Franco V, Vincelli D, Pileri A Jr, Gasbarra R, Falini B, Zinzani PL, Baccarani M (2007) Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia 21:340–350PubMedCrossRefGoogle Scholar
- 7.Agis H, Weltermann A, Fonatsch C, Haas O, Mitterbauer G, Müllauer L, Schreiber S, Schwarzinger I, Juretzka W, Valent P, Jäger U, Lechner K, Geissler K (2002) A comparative study on demographic, hematological, and cytogenetic findings and prognosis in acute myeloid leukemia with and without leukemia cutis. Ann Hematol 81:90–95PubMedCrossRefGoogle Scholar