Annals of Hematology

, Volume 93, Issue 4, pp 709–710 | Cite as

MLL-AF9 rearrangement in myeloid sarcomas involving the breast

  • Boting Wu
  • Feng Li
  • Shanhua Zou
Letter to the Editor

Dear Editor,

A 29-year-old woman (patient 1) presented to our facility in August 2011 for migrating arthralgia at bilateral elbow and knee joints. CT scan revealed coarse articular surface of bilateral sacroiliac joints with slight irregularity. Serological tests for autoantibodies were all negative. Three months later, palpable masses were sequentially reported at the left and right breast. Fine needle biopsy of the left breast indicated malignancy with hematopoietic origin. Bone marrow aspiration revealed acute myeloid leukemia with FAB AML-M4 morphology. Flow cytometric study showed 21 % malignant cells of marrow sample, which had an expression of surface markers including CD117, CD33, CD38, CD15, CD64, CD4, and CD56. Malignant cells possessed a recurrent cytogenetic aberration shown by G-banding as 47, XX, + 8, t(9;11)(p22;q23). Further molecular surveys confirmed the existence of an MLL-AF9 fusion gene. Patient 2 was a 28-year-old woman who presented to our facility in October...


Acute Myeloid Leukemia Idarubicin Bone Marrow Aspiration Fine Needle Biopsy Bone Marrow Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest

None of the contributors have any potential conflicts of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of HematologyZhongshan Hospital Fudan UniversityShanghaiChina
  2. 2.Department of TransfusionZhongshan Hospital Fudan UniversityShanghaiChina

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