Isolated central nervous system relapse presenting as myeloid sarcoma of acute myeloid leukemia after allogeneic peripheral blood stem cell transplantation
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A 27-year-old female had acute myeloid leukemia (AML), M4 of French–American–British (FAB) classification with cytogenetic abnormalities of inversion (16) and trisomy 8. Immunophenotyping was positive for CD33, CD13, CD15, CD11b, CD34, and HLA-DR. She achieved complete remission after induction chemotherapy (idarubicin 12 mg/m2/day for 3 days and cytarabine 200 mg/m2/day for 7 days) and four courses of consolidation therapy (cytarabine 3 g/day over 5 days). After 4 months, she had a relapse, with 60 % blast cells in the bone marrow, and received salvage chemotherapy (mitoxantron 12 mg/m2/day for 3 days and etoposide 100 mg/m2/day for 3 days) and again achieved complete remission. She underwent allogeneic peripheral blood stem cell transplantation (PBSCT) from an HLA-matched, related female donor with a conditioning regimen of cyclophosphamide (60 mg/kg/day for 2 days), etoposide (60 mg/kg for 1 day), and 12 Gy total body irradiation. Prophylaxis for graft-versus-host...
KeywordsAcute Myeloid Leukemia Peripheral Blood Stem Cell Transplantation Bone Marrow Examination Central Nervous System Relapse Myeloid Sarcoma
Conflict of interest
The author(s) declare that they have no potential conflicts of interest.
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