Annals of Hematology

, Volume 91, Issue 9, pp 1393–1401 | Cite as

Ophthalmologic outcomes after chemotherapy and/or radiotherapy in non-conjunctival ocular adnexal MALT lymphoma

  • Ji-Sun Paik
  • Won-Kyung Cho
  • Sung-Eun Lee
  • Byung-Ock Choi
  • Seung-Eun Jung
  • Gyeong-Sin Park
  • Sung-Hoon Kim
  • Suk-Woo YangEmail author
  • Seok-Goo ChoEmail author
Original Article


In the present study, we evaluated the ophthalmologic outcomes of 24 patients who received chemotherapy and/or radiotherapy for the treatment of non-conjunctival ocular adnexal mucosa-associated lymphoid tissue-type (MALT) lymphoma. Ophthalmologic outcomes were assessed in patients who received chemotherapy and/or radiotherapy from March 2004 until May 2010. Outcomes were determined according to common symptoms following chemotherapy and/or radiotherapy, which consisted of decreased visual acuity, dry eye symptoms, retinopathy, optic neuropathy, increased intraocular pressure, and blepharitis. Nine patients received chemotherapy alone, eight patients received radiotherapy alone, and seven patients received chemotherapy with additional radiotherapy (chemoradiation therapy). Patients treated by chemotherapy alone showed better ophthalmologic outcome scores (mean score, 1.56) than those treated by radiation alone or chemoradiation therapy (mean score, 4.01). In conclusion, the treatment of ocular adnexal lymphoma including radiotherapy showed poor ophthalmologic outcomes due to radiation-induced complications. Recently, many new treatment options have emerged, such as immunotherapy or radioimmunotherapy. In the future study, to select a better treatment modality with fewer complications, well-designed prospective trials with ophthalmologic outcomes are needed.


Non-conjunctival MALT lymphoma Ophthalmologic outcomes Radiotherapy Chemotherapy 



The authors did not receive any funding or financial support.


The authors do not have anything to disclose. The authors do not have financial interest for the treatment of ocular adnexal lymphoma.

This paper was not presented in any other international meetings.

Competing interests

None to declare. No conflicting relationship exists for any authors.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Ji-Sun Paik
    • 1
    • 7
  • Won-Kyung Cho
    • 1
    • 7
  • Sung-Eun Lee
    • 2
    • 7
  • Byung-Ock Choi
    • 3
    • 7
  • Seung-Eun Jung
    • 4
    • 7
  • Gyeong-Sin Park
    • 5
    • 7
  • Sung-Hoon Kim
    • 6
    • 7
  • Suk-Woo Yang
    • 1
    • 7
    Email author
  • Seok-Goo Cho
    • 2
    • 7
    Email author
  1. 1.Department of Ophthalmology and Visual Science, College of Medicine, Seoul St. Mary’s HospitalThe Catholic University of KoreaSeoulRepublic of Korea
  2. 2.Department of Hematology, Catholic BMT Center, Seoul St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea
  3. 3.Department of Radiation Oncology, Seoul St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaSeoulSouth Korea
  4. 4.Department of Radiology, Seoul St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaSeoulSouth Korea
  5. 5.Department of Pathology, Seoul St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaSeoulSouth Korea
  6. 6.Department of Nuclear Medicine, Seoul St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaSeoulSouth Korea
  7. 7.Catholic University Lymphoma GroupThe Catholic University of KoreaSeoulSouth Korea

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