Bendamustine with or without rituximab for the treatment of heavily pretreated non-Hodgkin’s lymphoma patients
Bendamustine is an alkylating agent with a nitrogen mustard group and a purine-like benzimidazole group. The aim of this study was to collect all the Italian experiences with this drug in order to evaluate the results in term of response to therapy and toxicities. We analyzed lymphoma patients treated in 24 Italian haematological centres with bendamustine alone or in combination with anti-CD20 antibody. One hundred seventy-five relapsed or refractory lymphoma patients were enrolled. The median age was 69 years (range 26–87). Seventy-nine patients were relapsed, 35 were refractory and 61 presented a progressive disease after partial response. The diagnoses were 60 indolent non-follicular lymphomas, 34 diffuse large B-cell lymphomas, 48 follicular lymphomas, 30 mantle cell lymphomas and three peripheral T-cell lymphomas. All patients were evaluable for response: 52 (29%) with complete remission, 72 (43%) with partial response with an overall response rate of 71%, and 51 non-responders. With a median observation period of 10 months (1–43), 70% of patients are alive. In summary, this retrospective study shows that treatment with bendamustine alone or in combination with rituximab is a safe and effective regimen in a subset of multi-resistant patients.
KeywordsBendamustine Rituximab Relapsed lymphoma Antineoplastic agents
The following researchers have substantially contributed to data acquisition: Maurizio Musso, UO Ematologia e Trapianto di Midollo, CDC "La Maddalena", Palermo; Pellegrino Musto, UO di Ematologia e Trapianto di Cellule Staminali, IRCCS-CROB, Rionero in Vulture; Teodoro Chisesi, UO Ematologia Mestre-Venezia; Nicola Di Renzo, UO Ematologia e Trapianto di cellule Staminali, P.O V. Fazzi, Lecce; Nicola Cascavilla, Ematologia IRCS Casa Sollievo della Sofferenza, San Giovanni Rotondo; Caterina Stelitano, UO Ematologia Ospedali Melacrino-Morelli, Reggio Calabria; and Mariella Sciacca, UO OncoEmatologia AO Sant’Andrea, Vercelli.
There are no financial disclosures from any authors.
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