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Annals of Hematology

, Volume 91, Issue 7, pp 1013–1022 | Cite as

Bendamustine with or without rituximab for the treatment of heavily pretreated non-Hodgkin’s lymphoma patients

A multicenter retrospective study on behalf of the Italian Lymphoma Foundation (FIL)
  • Luigi RigacciEmail author
  • Benedetta Puccini
  • Sergio Cortelazzo
  • Gianluca Gaidano
  • Andrea Piccin
  • Alfonso D’Arco
  • Roberto Freilone
  • Sergio Storti
  • Enrico Orciuolo
  • Pier Luigi Zinzani
  • Francesco Zaja
  • Velia Bongarzoni
  • Monica Balzarotti
  • Delia Rota-Scalabrini
  • Caterina Patti
  • Marco Gobbi
  • Andrea Carpaneto
  • Anna Marina Liberati
  • Alberto Bosi
  • Emilio Iannitto
Original Article

Abstract

Bendamustine is an alkylating agent with a nitrogen mustard group and a purine-like benzimidazole group. The aim of this study was to collect all the Italian experiences with this drug in order to evaluate the results in term of response to therapy and toxicities. We analyzed lymphoma patients treated in 24 Italian haematological centres with bendamustine alone or in combination with anti-CD20 antibody. One hundred seventy-five relapsed or refractory lymphoma patients were enrolled. The median age was 69 years (range 26–87). Seventy-nine patients were relapsed, 35 were refractory and 61 presented a progressive disease after partial response. The diagnoses were 60 indolent non-follicular lymphomas, 34 diffuse large B-cell lymphomas, 48 follicular lymphomas, 30 mantle cell lymphomas and three peripheral T-cell lymphomas. All patients were evaluable for response: 52 (29%) with complete remission, 72 (43%) with partial response with an overall response rate of 71%, and 51 non-responders. With a median observation period of 10 months (1–43), 70% of patients are alive. In summary, this retrospective study shows that treatment with bendamustine alone or in combination with rituximab is a safe and effective regimen in a subset of multi-resistant patients.

Keywords

Bendamustine Rituximab Relapsed lymphoma Antineoplastic agents 

Notes

Acknowledgements

The following researchers have substantially contributed to data acquisition: Maurizio Musso, UO Ematologia e Trapianto di Midollo, CDC "La Maddalena", Palermo; Pellegrino Musto, UO di Ematologia e Trapianto di Cellule Staminali, IRCCS-CROB, Rionero in Vulture; Teodoro Chisesi, UO Ematologia Mestre-Venezia; Nicola Di Renzo, UO Ematologia e Trapianto di cellule Staminali, P.O V. Fazzi, Lecce; Nicola Cascavilla, Ematologia IRCS Casa Sollievo della Sofferenza, San Giovanni Rotondo; Caterina Stelitano, UO Ematologia Ospedali Melacrino-Morelli, Reggio Calabria; and Mariella Sciacca, UO OncoEmatologia AO Sant’Andrea, Vercelli.

Financial disclosures

There are no financial disclosures from any authors.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Luigi Rigacci
    • 1
    • 18
    Email author
  • Benedetta Puccini
    • 1
  • Sergio Cortelazzo
    • 2
  • Gianluca Gaidano
    • 3
  • Andrea Piccin
    • 2
  • Alfonso D’Arco
    • 4
  • Roberto Freilone
    • 5
  • Sergio Storti
    • 6
  • Enrico Orciuolo
    • 7
  • Pier Luigi Zinzani
    • 8
  • Francesco Zaja
    • 9
  • Velia Bongarzoni
    • 10
  • Monica Balzarotti
    • 11
  • Delia Rota-Scalabrini
    • 12
  • Caterina Patti
    • 13
  • Marco Gobbi
    • 14
  • Andrea Carpaneto
    • 15
  • Anna Marina Liberati
    • 16
  • Alberto Bosi
    • 1
  • Emilio Iannitto
    • 17
  1. 1.SOD EmatologiaAzienda Ospedaliero Universitaria CareggiFlorenceItaly
  2. 2.UO Ematologia e TMOOspedale Regionale San MaurizioBolzanoItaly
  3. 3.Division of Hematology, Department of Clinical and Experimental MedicineUniversità del Piemonte Orientale Amedeo AvogadroNovaraItaly
  4. 4.UO EmatologiaNocera InferioreItaly
  5. 5.SC Medicina Trasfusionale ed Ematologia ASLTO4 CirièTorinoItaly
  6. 6.U.O OncoEmatologiaUniversità Cattolica del Sacro CuoreCampobassoItaly
  7. 7.UO EmatologiaAzienda Ospedaliero Universitaria PisanaPisaItaly
  8. 8.Istituto di Ematologia “Seràgnoli”Università e Ospedale S. OrsolaBolognaItaly
  9. 9.Clinica Ematologica, Centro Trapianti e Terapia Cellulari “Carlo Melzi”Azienda Ospedaliero Universitaria S. M. MisericordiaUdineItaly
  10. 10.UO EmatologiaAzienda Ospedaliera “S. Giovanni Addolorata”RomeItaly
  11. 11.Hematology UnitHumanitas Cancer Center RozzanoMilanItaly
  12. 12.IRCC FPOCandioloItaly
  13. 13.U.O. EmatologiaA.O. Villa Sofia-CervelloPalermoItaly
  14. 14.Clinica Ematologica, Dipartimento di Ematologia e OncologiaOspedale San MartinoGenoaItaly
  15. 15.U.O EmatologiaRonciglioneItaly
  16. 16.Sezione Medicina Interna e Scienza OncologicheAzienda Ospedaliera S. Maria TerniTerniItaly
  17. 17.UO EmatologiaAOUP Paolo GiacconePalermoItaly
  18. 18.Division of Hematology and Bone Marrow TransplantationAzienda Ospedaliera Universitaria CareggiFlorenceItaly

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