Annals of Hematology

, Volume 91, Issue 7, pp 1139–1141

Extravascular hemolytic attack after eculizumab therapy for paroxysmal nocturnal hemoglobinuria

  • Akihiro Tomita
  • Yukari Shirasugi
  • Takahiko Ito
  • Hisashi Tsurumi
  • Tomoki Naoe
Letter to the Editor

References

  1. 1.
    Luzzatto L, Gianfaldoni G, Notaro R (2011) Management of paroxysmal nocturnal haemoglobinuria: a personal view. Br J Haematol 153(6):709–720PubMedCrossRefGoogle Scholar
  2. 2.
    Berzuini A, Montanelli F, Prati D (2010) Hemolytic anemia after eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med 363(10):993–994PubMedCrossRefGoogle Scholar
  3. 3.
    Hill A, Rother RP, Wang X, Morris SM Jr, Quinn-Senger K, Kelly R, Richards SJ, Bessler M, Bell L, Hillmen P, Gladwin MT (2010) Effect of eculizumab on haemolysis-associated nitric oxide depletion, dyspnoea, and measures of pulmonary hypertension in patients with paroxysmal nocturnal haemoglobinuria. Br J Haematol 149(3):414–425PubMedCrossRefGoogle Scholar
  4. 4.
    Risitano AM, Notaro R, Luzzatto L, Hill A, Kelly R, Hillmen P (2010) Paroxysmal nocturnal hemoglobinuria–hemolysis before and after eculizumab. N Engl J Med 363(23):2270–2272PubMedCrossRefGoogle Scholar
  5. 5.
    Risitano AM, Notaro R, Marando L, Serio B, Ranaldi D, Seneca E, Ricci P, Alfinito F, Camera A, Gianfaldoni G, Amendola A, Boschetti C, Di Bona E, Fratellanza G, Barbano F, Rodeghiero F, Zanella A, Iori AP, Selleri C, Luzzatto L, Rotoli B (2009) Complement fraction 3 binding on erythrocytes as additional mechanism of disease in paroxysmal nocturnal hemoglobinuria patients treated by eculizumab. Blood 113(17):4094–4100PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Akihiro Tomita
    • 1
  • Yukari Shirasugi
    • 2
  • Takahiko Ito
    • 3
  • Hisashi Tsurumi
    • 4
  • Tomoki Naoe
    • 1
  1. 1.Department of Hematology and OncologyNagoya University Graduate School of MedicineNagoyaJapan
  2. 2.Department of Hematology and OncologyTokai University HospitalIseharaJapan
  3. 3.Department of HematologyGifu Social Insurance HospitalKaniJapan
  4. 4.First Department of Internal MedicineGifu University Graduate School of MedicineGifuJapan

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