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Annals of Hematology

, Volume 91, Issue 4, pp 561–570 | Cite as

Treatment of B cell lymphoma with chemotherapy plus rituximab: a survival benefit can be demonstrated in the routine data of a regional cancer registry

  • Stefan W. Krause
  • Michael Gerken
  • Reinhard Andreesen
  • Ferdinand Hofstädter
  • Monika Klinkhammer-Schalke
Original Article

Abstract

Combination of standard chemotherapy with rituximab led to improved disease control in patients with B cell lymphoma in clinical trials. We wanted to know if a similar benefit could be demonstrated in the routine data of a regional population-based cancer registry. We searched the registry of the Regensburg Tumor Center for B cell non-Hodgkin lymphomas diagnosed between 1998 and 2006 and compared overall survival of patients receiving any first-line chemotherapy with or without rituximab. Comparing registry data to death certificates, an 86% coverage within the registry was estimated. In the aggressive lymphoma group, 133 patients received rituximab-containing chemotherapy resulting in a 5-year survival of 69.6%, whereas 205 patients received chemotherapy alone with a significantly inferior 5-year survival of 56.8%. First-line chemotherapy with rituximab in 81 patients with indolent lymphoma also led to improved 5-year survival compared to 134 patients without rituximab (69.7% vs. 51.8%), primarily observed among patients with follicular lymphoma (84.7% vs. 52.0%). These data confirm the standard use of rituximab as first-line therapy in diffuse large B cell lymphomas as well as in indolent lymphoma. Furthermore, they support the collection of treatment data including detailed information on systemic therapy in cancer registries to be used for outcomes research.

Keywords

Lymphoma Non-Hodgkin Chemotherapy Rituximab Cancer registry 

Notes

Acknowledgments

The authors would like to thank the medical documentation assistants of the cancer registry, notably Christine Glötzl, Martina Kirchberger, and Doris Weinberger, for their contribution regarding a standardized encoding of the non-Hodgkin lymphomas and all members of the Tumorzentrum who contributed data to the registry.

Funding/disclosures

This study was not supported by pharmaceutical companies. SWK has received travel support from Roche. RA has received support for scientific meetings from Roche. The other authors have not reported any potential conflicts of interest.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Stefan W. Krause
    • 4
    • 5
  • Michael Gerken
    • 1
  • Reinhard Andreesen
    • 1
    • 3
  • Ferdinand Hofstädter
    • 1
    • 2
  • Monika Klinkhammer-Schalke
    • 1
  1. 1.Tumorzentrum RegensburgRegensburgGermany
  2. 2.Institute of PathologyUniversity HospitalRegensburgGermany
  3. 3.Department of Hematology and Medical OncologyUniversity Hospital RegensburgRegensburgGermany
  4. 4.Department of Hematology and Medical OncologyUniversity Hospital ErlangenErlangenGermany
  5. 5.Medizinische Klinik 5-Hämatologie und Internistische OnkologieKlinikum der Universität ErlangenErlangenGermany

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