Screening for hereditary spherocytosis in routine practice: evaluation of a diagnostic algorithm with focus on non-splenectomised patients
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We have read with interest the recent paper of Mullier et al.  about the development of the hereditary spherocytosis (HS) diagnostic tool. The authors state that this diagnostic tool has a sensitivity of 100%, specificity of 99.3%, positive predictive value (PPV) of 75% and negative predictive value (NPV) of 100% and could be used routinely as an excellent screening method for the diagnosis of HS. As a university hospital, we have a large population of patients diagnosed with HS. Using our laboratory database, we evaluated retrospectively the value of the HS diagnostic tool. Complete data (reticulocytes and research parameters) were obtained from in total 2,593 individuals (including 25 patients with clinical diagnosis of HS) during the period July 2010 till December 2010. All measurements were performed on the XE-5000 (Sysmex, Kobe, Japan) as necessary for the tool.
KeywordsDiagnostic Tool Positive Predictive Value Negative Predictive Value Routine Practice Reticulocyte Count
- 1.Mullier F, Lainey E, Fenneteau O, Da Costa L, Schillinger F, Bailly N, Cornet Y, Chatelain C, Dogne JM, Chatelain B (2010) Additional erythrocytic and reticulocytic parameters helpful for diagnosis of hereditary spherocytosis: results of a multicentre study. Ann Hematol doi: 10.1007/s00277-010-1138-3
- 2.Mariana M, Barcellini W, Vercellati C, Marcello A, Fermo E, Pedotti P, Boschetti C, Zanella A (2008) Clinical and hematologic features of 300 patients affected by hereditary spherocytosis grouped according to the type of the membrane protein defect. Haematologica 93(9):1310–1317CrossRefGoogle Scholar