Annals of Hematology

, Volume 90, Issue 6, pp 693–699 | Cite as

Pilot study of pegylated interferon alpha-2a treatment during chemo- and radiotherapy and post-remission maintenance in patients with EBV-positive extranodal NK/T cell lymphoma

  • Sung-Yong Kim
  • Seok-Goo ChoEmail author
  • Sung-Won Kim
  • Byung-Ok Choi
  • Kyung-Sin Park
  • Jihyang Lim
  • Chang-Ki Min
  • Yong-Goo Kim
  • Jong-Wook Lee
  • Woo-Sung Min
Original Article


The role of the Epstein–Barr virus (EBV) in the pathogenesis of extranodal natural killer/T-cell lymphoma (ENKTCL), and its resistance to chemotherapy raises the possibility of antiviral therapeutic strategies. The aim of this prospective pilot study was to evaluate the feasibility and effectiveness of antiviral treatment using pegylated interferon alpha-2a (pIFN α-2a) as an adjunct to induction and maintenance therapy in patients with ENKTCL. A total of seven patients with newly diagnosed EBV-positive ENKTCL were enrolled. Pegylated IFN α-2a was administered during induction chemoradiotherapy. If patients achieved a partial or complete response (PR or CR, respectively), high-dose chemotherapy with autologous stem cell transplantation (HDT/SCT) was given. After transplantation, maintenance therapy included pIFN α-2a for 3 years. Of the patients available for evaluation, all achieved a CR or PR after induction therapy but one patient relapsed before HDT/SCT. The event free survival and overall survival at 3 years were 50.0 ± 20.4% and 66.7 ± 19.2%, respectively. The 3-year disease-free survival after transplantation of the patients that received maintenance therapy was 80.0 ± 17.9%. The results of this pilot study indicated that pIFN α-2a containing induction and maintenance therapy was feasible and effective for ENKTCL.


Extranodal NK/T cell lymphoma Epstein–Barr virus Interferon alpha-2a 



This study was supported by grants from the Korea Science and Engineering Foundation (R11-2002-098-08004-0) and from the Catholic Institute of Cell Therapy Basic Science Programs Foundation during the program year 2007. The study was, in part, sponsored by Roche Pharmaceutical.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Sung-Yong Kim
    • 1
  • Seok-Goo Cho
    • 2
    Email author
  • Sung-Won Kim
    • 3
  • Byung-Ok Choi
    • 4
  • Kyung-Sin Park
    • 5
  • Jihyang Lim
    • 6
  • Chang-Ki Min
    • 2
  • Yong-Goo Kim
    • 6
  • Jong-Wook Lee
    • 2
  • Woo-Sung Min
    • 2
  1. 1.Department of Hematology/Oncology, KonKuk University Medical CenterKonKuk UniversitySeoulSouth Korea
  2. 2.Catholic Blood and Marrow Transplantation Center, Seoul St. Mary’s HospitalThe Catholic University of KoreaSeoulSouth Korea
  3. 3.Department of Otolaryngology-Head and Neck SurgeryThe Catholic University of KoreaSeoulSouth Korea
  4. 4.Department of Radiation OncologyThe Catholic University of KoreaSeoulSouth Korea
  5. 5.Department of PathologyThe Catholic University of KoreaSeoulSouth Korea
  6. 6.Department of Laboratory Medicine, College of MedicineThe Catholic University of KoreaSeoulSouth Korea

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