Seven-year response to imatinib as initial treatment versus re-treatment in Chinese patients with chronic myelogenous leukemia in the chronic phase
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The purpose of our study is to compare the 7-year response to imatinib monotherapy as an initial treatment and re-treatment in Chinese patients with chronic myelogenous leukemia-chronic phase (CML-CP) patients in a single center in Beijing. A retrospective study of 171 CML-CP patients receiving imatinib monotherapy was done with 73 in the initial treatment group (disease course ≤6 months) and 98 in the re-treatment group (disease course >6 months). Cumulative rates of complete cytogenetic response (CCyR) at 6, 12, and 36 months after imatinib treatment in the initial and re-treatment groups were 75%, 89%, and 96%, and 48%, 77% and 84% (p = 0.0002), respectively. The median time to CCyR in the initial and re-treatment groups was 6 months (95% CI, 3.3–8.3) and 9 months (95% CI, 6.4–11.6), respectively (p = 0.0002). Cumulative rates of major molecular responses at 9, 12, and 18 months after imatinib treatment in the initial and re-treatment groups were 31%, 48%, and 60%, and 15%, 25% and 37% (p = 0.017), respectively. The median time to the major molecular response in the initial and re-treatment groups was 15 months (95% CI, 12.3–17.7) and 36 months (95% CI, 25.9–46.0), respectively (p = 0.017). Progression-free survival at 84 months in the initial and re-treatment groups was 97% and 85%, respectively (p = 0.09). Event-free survival at 84 months in the initial and re-treatment groups was 92% and 70%, respectively (p = 0.049). Only two of the 171 patients discontinued imatinib therapy for grade 3/4 adverse events. Our study revealed that CML-CP patients would benefit from early treatment with imatinib.
KeywordsChronic myeloid leukemia Imatinib Cytogenetic response Molecular response Event-free survival
The authors would like to thank the contributions of all the people who have participated in this research. This includes our laboratory staff, our colleagues, and our nurses. During April 2001 to April 2002, 46 patients in our study had enrolled in the international phase II expanded clinical trial of imatinib mesylate sponsored by Novartis. Imatinib for patients for 9 months every year was supplied by the Glivec International Patient Assistance Program (Novartis)—patients paid for the other 3 months each year themselves.
Supported by the program for innovative research team in the university (grant No. IRT 0702)
Authorship and Disclosures
JH, CSS, JB, and JQ received research grants from Novartis in the course of the international phase II expanded clinical trial of imatinib mesylate in China from April 2001 to April 2002. All other authors declare no competing financial interests. HXJ takes responsibility for the paper. JH, CSS, JB, and JQ recruited the patients. QYZ and LYY performed the laboratory work for this study. HXJ and JH coordinated the research. JH participated in the statistical analysis. HXJ and JH wrote the paper.
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